| Effect of synthetic estrogen on platelet aggregation and vascular release of PGI2-like material in the rabbit. | |
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MedLine Citation:
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PMID: 7010445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment of adult female New Zealand white rabbits with ethinyl estradiol, the synthetic estrogen used in many oral contraceptives, results in a significant increase in in vivo aggregation. This alteration in platelet behavior is accompanied by diminished vascular release of antiaggregatory PGI2 (prostacyclin)-like material. Addition of a progestin prevents the change in platelet aggregation seen with the estrogen alone. Diminished vascular PGI2 release may be an important factor in the pathogenesis of thrombotic occurrences experienced by some oral contraceptive users. In vivo platelet aggregation may be of value in identifying individuals at risk of developing thrombotic disturbances while taking oral contraceptives. |
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Authors:
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M B Elam; G E Lipscomb; C M Chesney; D A Terragno; N A Terragno |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Prostaglandins Volume: 20 ISSN: 0090-6980 ISO Abbreviation: Prostaglandins Publication Date: 1980 Dec |
Date Detail:
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Created Date: 1981-05-13 Completed Date: 1981-05-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0320271 Medline TA: Prostaglandins Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1039-51 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate
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pharmacology Animals Aorta / drug effects, metabolism Collagen / pharmacology Epoprostenol / blood* Ethinyl Estradiol / pharmacology* Female Norethindrone / pharmacology Platelet Aggregation / drug effects* Progestins / pharmacology Prostaglandins / blood* Rabbits |
| Grant Support | |
ID/Acronym/Agency:
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HL-18650/HL/NHLBI NIH HHS; HL-22225/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Progestins; 0/Prostaglandins; 35121-78-9/Epoprostenol; 57-63-6/Ethinyl Estradiol; 58-64-0/Adenosine Diphosphate; 68-22-4/Norethindrone; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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