Document Detail


Effect of synthetic estrogen on platelet aggregation and vascular release of PGI2-like material in the rabbit.
MedLine Citation:
PMID:  7010445     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Treatment of adult female New Zealand white rabbits with ethinyl estradiol, the synthetic estrogen used in many oral contraceptives, results in a significant increase in in vivo aggregation. This alteration in platelet behavior is accompanied by diminished vascular release of antiaggregatory PGI2 (prostacyclin)-like material. Addition of a progestin prevents the change in platelet aggregation seen with the estrogen alone. Diminished vascular PGI2 release may be an important factor in the pathogenesis of thrombotic occurrences experienced by some oral contraceptive users. In vivo platelet aggregation may be of value in identifying individuals at risk of developing thrombotic disturbances while taking oral contraceptives.
Authors:
M B Elam; G E Lipscomb; C M Chesney; D A Terragno; N A Terragno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Prostaglandins     Volume:  20     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-05-13     Completed Date:  1981-05-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1039-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Diphosphate / pharmacology
Animals
Aorta / drug effects,  metabolism
Collagen / pharmacology
Epoprostenol / blood*
Ethinyl Estradiol / pharmacology*
Female
Norethindrone / pharmacology
Platelet Aggregation / drug effects*
Progestins / pharmacology
Prostaglandins / blood*
Rabbits
Grant Support
ID/Acronym/Agency:
HL-18650/HL/NHLBI NIH HHS; HL-22225/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Progestins; 0/Prostaglandins; 35121-78-9/Epoprostenol; 57-63-6/Ethinyl Estradiol; 58-64-0/Adenosine Diphosphate; 68-22-4/Norethindrone; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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