Document Detail

Effect of synergic dietary calcium enrichment and induced ferropenic anemia on antioxidant enzymes activity in rats.
MedLine Citation:
PMID:  20591624     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: The aim of this study was to examine the synergism of dietary calcium enrichment (added to goat's or cow's milk) and induced nutritional ferropenic anemia on oxidative status.
METHODS: Control rats and rats with induced nutritional ferropenic anemia were fed for 14 d with diets containing normal (5000 mg/kg) or double (10 000 mg/kg) the recommended calcium content. Thiobarbituric acid-reactive substances in plasma were measured, as were the activities of the antioxidant enzyme catalase, copper/zinc superoxide dismutase, and glutathione peroxidase in erythrocyte cytosol.
RESULTS: Dietary calcium enrichment did not affect oxidative stress as assessed by thiobarbituric acid-reactive substances; however, it significantly upregulated the activities of some antioxidant enzymes examined in the erythrocyte cytosol. In particular, adding calcium to standard or milk-based diets significantly increased glutathione peroxidase activity in control and anemic rats and copper/zinc superoxide dismutase activity in control rats.
CONCLUSION: The increased activities of glutathione peroxidase and copper/zinc superoxide dismutase induced by dietary calcium enrichment suggest that calcium supplementation may protect against oxidative stress even in nutritionally induced ferropenic anemia.
Teresa Nestares; Inmaculada López-Aliaga; María J M Alférez; Javier Díaz-Castro; Angeles Amat; Margarita S Campos
Related Documents :
8019384 - Effect of different doses of dietary calcium on murine colonic cell proliferation.
16402634 - The effect of d-003 (10 mg/day) on biochemical parameters of bone remodelling in postme...
22231784 - Liver patt1 deficiency protects male mice from age-associated but not high-fat diet-ind...
21658924 - Postnatal essential fatty acid deficiency in mice affects lipoproteins, hepatic lipids,...
21720074 - Comparison of fat suppression techniques of bilateral breast dynamic sequence at 3.0 t:...
22445154 - Oxidized oils and dietary zinc and α-tocopheryl acetate supplementation: effects on ra...
Publication Detail:
Type:  Journal Article     Date:  2010-07-01
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  27     ISSN:  1873-1244     ISO Abbreviation:  Nutrition     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  576-81     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Physiology and Institute of Nutrition and Food Technology "José Mataix", University of Granada, Granada, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Percutaneous closure of a left atrial appendage pseudoaneurysm.
Next Document:  Low-dose creatine supplementation enhances fatigue resistance in the absence of weight gain.