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Effect of synergic dietary calcium enrichment and induced ferropenic anemia on antioxidant enzymes activity in rats.
MedLine Citation:
PMID:  20591624     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study was to examine the synergism of dietary calcium enrichment (added to goat's or cow's milk) and induced nutritional ferropenic anemia on oxidative status.
METHODS: Control rats and rats with induced nutritional ferropenic anemia were fed for 14 d with diets containing normal (5000 mg/kg) or double (10 000 mg/kg) the recommended calcium content. Thiobarbituric acid-reactive substances in plasma were measured, as were the activities of the antioxidant enzyme catalase, copper/zinc superoxide dismutase, and glutathione peroxidase in erythrocyte cytosol.
RESULTS: Dietary calcium enrichment did not affect oxidative stress as assessed by thiobarbituric acid-reactive substances; however, it significantly upregulated the activities of some antioxidant enzymes examined in the erythrocyte cytosol. In particular, adding calcium to standard or milk-based diets significantly increased glutathione peroxidase activity in control and anemic rats and copper/zinc superoxide dismutase activity in control rats.
CONCLUSION: The increased activities of glutathione peroxidase and copper/zinc superoxide dismutase induced by dietary calcium enrichment suggest that calcium supplementation may protect against oxidative stress even in nutritionally induced ferropenic anemia.
Authors:
Teresa Nestares; Inmaculada López-Aliaga; María J M Alférez; Javier Díaz-Castro; Angeles Amat; Margarita S Campos
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Publication Detail:
Type:  Journal Article     Date:  2010-07-01
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  27     ISSN:  1873-1244     ISO Abbreviation:  Nutrition     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  576-81     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Physiology and Institute of Nutrition and Food Technology "José Mataix", University of Granada, Granada, Spain.
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