| Effect of synergic dietary calcium enrichment and induced ferropenic anemia on antioxidant enzymes activity in rats. | |
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MedLine Citation:
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PMID: 20591624 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to examine the synergism of dietary calcium enrichment (added to goat's or cow's milk) and induced nutritional ferropenic anemia on oxidative status. METHODS: Control rats and rats with induced nutritional ferropenic anemia were fed for 14 d with diets containing normal (5000 mg/kg) or double (10 000 mg/kg) the recommended calcium content. Thiobarbituric acid-reactive substances in plasma were measured, as were the activities of the antioxidant enzyme catalase, copper/zinc superoxide dismutase, and glutathione peroxidase in erythrocyte cytosol. RESULTS: Dietary calcium enrichment did not affect oxidative stress as assessed by thiobarbituric acid-reactive substances; however, it significantly upregulated the activities of some antioxidant enzymes examined in the erythrocyte cytosol. In particular, adding calcium to standard or milk-based diets significantly increased glutathione peroxidase activity in control and anemic rats and copper/zinc superoxide dismutase activity in control rats. CONCLUSION: The increased activities of glutathione peroxidase and copper/zinc superoxide dismutase induced by dietary calcium enrichment suggest that calcium supplementation may protect against oxidative stress even in nutritionally induced ferropenic anemia. |
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Authors:
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Teresa Nestares; Inmaculada López-Aliaga; María J M Alférez; Javier Díaz-Castro; Angeles Amat; Margarita S Campos |
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Publication Detail:
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Type: Journal Article Date: 2010-07-01 |
Journal Detail:
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Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 27 ISSN: 1873-1244 ISO Abbreviation: Nutrition Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802712 Medline TA: Nutrition Country: United States |
Other Details:
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Languages: eng Pagination: 576-81 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Physiology and Institute of Nutrition and Food Technology "José Mataix", University of Granada, Granada, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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