Document Detail

Effect of sympathetic stimulation on inactive renin.
MedLine Citation:
PMID:  6129086     Owner:  NLM     Status:  MEDLINE    
In the present study we investigated the effect of three manoeuvres known to be associated with enhanced sympathetic activity on plasma levels of active and inactive renin. To this end, active and trypsin-activatable renin were measured in blood drawn from 12 untreated essential hypertensive patients before, during and after any of the following tests: isometric exercise (handgrip), noise stimulation and 45 degrees head-up tilt. These studies were repeated after the patients had been treated with either atenolol (n = 6) or SL 77499 (n = 6), an alpha-1 adrenoceptor blocking agent for 10 days. The results indicate that active and inactive renin often change in an unpredictable way in response to sympathetic stimulation. There are, as yet, no conclusive explanations which describe the behaviour of both forms of renin during these manoeuvres.
P W de Leeuw; R de Bos; G A van Soest; P J Willemse; W H Birkenhäger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  4     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1982  
Date Detail:
Created Date:  1983-02-25     Completed Date:  1983-02-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2285-91     Citation Subset:  IM; S    
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MeSH Terms
Acoustic Stimulation
Adrenergic alpha-Antagonists / diagnostic use
Atenolol / diagnostic use
Blood Pressure / drug effects
Enzyme Precursors / blood*
Heart Rate / drug effects
Hypertension / physiopathology*
Middle Aged
Organic Chemicals
Physical Exertion
Renin / blood*
Sympathetic Nervous System / physiopathology*
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Enzyme Precursors; 0/Organic Chemicals; 29122-68-7/Atenolol; 86163-78-2/SL 77499; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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