Document Detail

Effect of sympathetic nerves on composition and distensibility of cerebral arterioles in rats.
MedLine Citation:
PMID:  2607446     Owner:  NLM     Status:  MEDLINE    
1. The goals of this study were to examine the effects of chronic sympathetic denervation on the mechanics and composition of cerebral arterioles in normotensive Wistar Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). 2. We used an in vivo method to examine the mechanics of pial arterioles in 10- to 12-month-old, anaesthetized WKY and SHRSP that had undergone unilateral removal of the superior cervical ganglion at 1 month of age. Bilateral craniotomies were performed in each rat to expose pial arterioles in the innervated and denervated cerebral hemispheres. Arterioles were deactivated with EDTA. Incremental distensibility and stress-strain relationships were calculated from measurements of pial arteriolar pressure (servo null), diameter and cross-sectional area of the arteriolar wall. Point counting stereology was used to quantify volume density and cross-sectional area of individual components in the arteriolar wall. 3. Chronic sympathetic denervation reduced cross-sectional area of the arteriolar wall by 16 +/- 2% (mean +/- S.E. of mean; P less than 0.05) in WKY and 44 +/- 3% in SHRSP. During maximal dilatation with EDTA, incremental distensibility was reduced and the stress-strain curve was shifted to the left in denervated arterioles of SHRSP, but not WKY. These findings indicate that sympathetic denervation in SHRSP attenuates the development of hypertrophy in pial arterioles and reduces arteriolar distensibility. The ratio of non-distensible (collagen and basement membrane) to distensible (smooth muscle, elastin and endothelium) components was reduced in denervated arterioles in SHRSP, but not WKY. 4. Thus, sympathetic nerves have trophic effects on cerebral arterioles in WKY and, to a greater degree, in SHRSP. Sympathetic nerves also contribute to increases in distensibility of cerebral arterioles in SHRSP, but not WKY. The increase in arteriolar distensibility is accompanied by a disproportionate increase in the more compliant elements of cerebral arterioles.
G L Baumbach; D D Heistad; J E Siems
Related Documents :
15489056 - Effects of life-long exercise on circulating free fatty acids and muscle triglyceride c...
18005246 - Voluntary running exercise attenuates the progression of endothelial dysfunction and ar...
25208266 - Impaired carbon monoxide diffusing capacity is the strongest lung function predictor of...
11374066 - Intracellular calibration of the fluorescent mg2+ indicator furaptra in rat ventricular...
3118656 - Transcutaneous monitoring of po2 and pco2 during running--a noninvasive determination o...
19381126 - Is exercise an effective treatment for nash? knowns and unknowns.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of physiology     Volume:  416     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1990-02-22     Completed Date:  1990-02-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  123-40     Citation Subset:  IM    
University of Iowa College of Medicine, Department of Pathology, Iowa City.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arterioles / innervation
Blood Pressure
Cerebral Arteries / innervation*,  physiology,  ultrastructure
Muscle, Smooth, Vascular / ultrastructure
Rats, Inbred SHR
Rats, Inbred WKY
Sympathetic Nervous System / physiology*
Tensile Strength
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Alterations in [Ca2+]i mediated by sodium-calcium exchange in smooth muscle cells isolated from the ...
Next Document:  Development of Y-axon innervation of cortical area 18 in the cat.