| Effect of switching carbamazepine to oxcarbazepine on the plasma levels of neuroleptics. A case report. | |
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MedLine Citation:
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PMID: 7862923 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carbamazepine was switched to its 10-keto analogue oxcarbazepine among six difficult-to-treat schizophrenic or organic psychotic patients using concomitantly haloperidol, chlorpromazine or clozapine. This change resulted within 2-4 weeks in the 50-200% increase in the plasma levels of these neuroleptics and the appearance of extrapyramidal symptoms. None of the patients showed any clinical deteriotation during the following 3-6 months. The results of this case report support the idea that in contrast with carbamazepine oxcarbazepine does not induce the hepatic microsomal enzyme systems regulating the inactivation of antipsychotic drugs. |
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Authors:
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V Raitasuo; R Lehtovaara; M O Huttunen |
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Publication Detail:
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Type: Case Reports; Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Psychopharmacology Volume: 116 ISSN: 0033-3158 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1995-03-23 Completed Date: 1995-03-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: GERMANY |
Other Details:
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Languages: eng Pagination: 115-6 Citation Subset: IM |
Affiliation:
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Kellokoski Hospital, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticonvulsants / adverse effects*, therapeutic use Antipsychotic Agents / adverse effects, blood*, therapeutic use Basal Ganglia Diseases / chemically induced Carbamazepine / adverse effects, analogs & derivatives*, therapeutic use Female Humans Male Psychotic Disorders / blood, drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Antipsychotic Agents; 28721-07-5/oxcarbazepine; 298-46-4/Carbamazepine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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