Document Detail

Effect of suxamethonium vs rocuronium on onset of oxygen desaturation during apnoea following rapid sequence induction.
MedLine Citation:
PMID:  20402874     Owner:  NLM     Status:  MEDLINE    
This study investigates the effect of suxamethonium vs rocuronium on the onset of haemoglobin desaturation during apnoea, following rapid sequence induction of anaesthesia. Sixty patients were randomly allocated to one of three groups. Anaesthesia was induced with lidocaine 1.5, fentanyl 2 and propofol 2, followed by either rocuronium 1 (Group R) or suxamethonium 1.5 (Group S). The third group received propofol 2 and suxamethonium 1.5 only (Group SO). The median (IQR [range]) time to reach S(p)O(2) of 95% was significantly shorter in Group S (358 (311-373 [245-430]) s) [corrected] than in Group R (378 (370-393 [366-420]) s; p = 0.003), and shorter in Group SO (242 (225-258 [189-270]) s) [corrected] than in both Group R (p < 0.001) and Group S (p < 0.001). When suxamethonium is administered for rapid sequence induction of anaesthesia, a faster onset of oxygen desaturation is observed during the subsequent apnoea compared with rocuronium. However, time to desaturation is prolonged whenever lidocaine and fentanyl precede suxamethonium.
S K Taha; M F El-Khatib; A S Baraka; Y A Haidar; F W Abdallah; R A Zbeidy; S M Siddik-Sayyid
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  65     ISSN:  1365-2044     ISO Abbreviation:  Anaesthesia     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-05-07     Revised Date:  2011-01-19    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  358-61     Citation Subset:  AIM; IM    
Department of Anesthesiology, American University of Beirut, Lebanon.
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MeSH Terms
Androstanols / adverse effects,  pharmacology*
Anesthesia, General / methods
Anesthetics, Intravenous / pharmacology
Anesthetics, Local / pharmacology
Apnea / blood
Fasciculation / chemically induced
Fentanyl / pharmacology
Intubation, Intratracheal
Lidocaine / pharmacology
Middle Aged
Neuromuscular Blockade / methods
Neuromuscular Depolarizing Agents / adverse effects,  pharmacology*
Neuromuscular Nondepolarizing Agents / adverse effects,  pharmacology*
Oxygen / blood*
Succinylcholine / adverse effects,  pharmacology*
Young Adult
Reg. No./Substance:
0/Androstanols; 0/Anesthetics, Intravenous; 0/Anesthetics, Local; 0/Neuromuscular Depolarizing Agents; 0/Neuromuscular Nondepolarizing Agents; 137-58-6/Lidocaine; 143558-00-3/rocuronium; 306-40-1/Succinylcholine; 437-38-7/Fentanyl; 7782-44-7/Oxygen
Comment In:
Anaesthesia. 2010 Sep;65(9):957; author reply 957-8   [PMID:  21198496 ]
Erratum In:
Anaesthesia. 2010 Aug;65(8):874

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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