| Effect of sustained-release isosorbide dinitrate on post-prandial gastric emptying and gastroduodenal motility in healthy humans. | |
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MedLine Citation:
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PMID: 15303766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitric oxide (NO) is an inhibitory neurotransmitter released by non-adrenergic and non-cholinergic neurons that innervate the smooth muscles of the gastrointestinal tract. We examined whether NO, derived from a sustained-release preparation of isosorbide dinitrate, influenced gastric emptying and gastroduodenal motility after a meal. Eleven healthy volunteers participated in a double-blind, placebo-controlled, cross-over study. Each subject ingested 40 mg isosorbide dinitrate orally as a sustained-release formulation or oral placebo, in random order. Gastric emptying and gastroduodenal motility were measured using scintigraphic and manometric techniques. Isosorbide dinitrate did not change the area under the curve of gastric retention versus time, and did not influence the frequency of antral contractions as assessed at 15-min intervals or the integrated duodenal motility index, as recorded over consecutive 15-min periods. A 40 mg single dose of sustained-released isosorbide dinitrate does not seem to alter gastric emptying or gastroduodenal motility after a meal. |
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Authors:
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J L Madsen; S L Rasmussen; J Linnet; S Fuglsang; J J Rumessen |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of international medical research Volume: 32 ISSN: 0300-0605 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2004 Jul-Aug |
Date Detail:
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Created Date: 2004-08-11 Completed Date: 2004-12-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
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Languages: eng Pagination: 351-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, University Hospital of Copenhagen, Denmark. jan.lysgaard.madsen@hh.hosp.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Cross-Over Studies Delayed-Action Preparations / administration & dosage, pharmacology Digestive System / drug effects Double-Blind Method Duodenum / drug effects* Female Gastric Emptying / drug effects* Gastrointestinal Motility / drug effects* Gastrointestinal Tract / drug effects Humans Isosorbide Dinitrate / administration & dosage*, pharmacology* Male Manometry Middle Aged Nitric Oxide / metabolism Nitric Oxide Donors / administration & dosage, pharmacology Placebos Postprandial Period Radionuclide Imaging Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 0/Nitric Oxide Donors; 0/Placebos; 10102-43-9/Nitric Oxide; 87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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