Document Detail

Effect of sustained maternal hyperglycaemia on the fetus in normal and diabetic pregnancies.
MedLine Citation:
PMID:  5008055     Owner:  NLM     Status:  MEDLINE    
The effect of prolonged maternal hyperglycaemia on fetal plasma glucose and insulin concentrations was investigated in eight normal and nine diabetic patients. It was found that under fasting conditions the fetal glucose concentration in gestational diabetic pregnancies tended to be lower than in normal pregnancies. Insulin measurements suggested that this may be due to fetal hyperinsulinism in the diabetic group. During glucose infusion, regardless of the degree of maternal hyperglycaemia, the fetal glucose concentration was limited in 12 out of 13 cases to less than 200 mg/100 ml, with only small differences between normal and diabetic pregnancies. It is proposed that the placenta prevents unlimited transport of glucose to the fetus; yet in diabetic pregnancies a sequence of increased maternal-fetal glucose transport, fetal hyperinsulinism, and fetal hypoglycaemia may contribute to the observed perinatal mortality.
N W Oakley; R W Beard; R C Turner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  1     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1972 Feb 
Date Detail:
Created Date:  1972-03-24     Completed Date:  1972-03-24     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  466-9     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Glucose / analysis*
Fetal Death / etiology
Fetus / metabolism*
Glucose / administration & dosage
Hyperglycemia / metabolism*
Insulin / blood*
Labor, Induced
Maternal-Fetal Exchange
Pregnancy in Diabetics / blood*
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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