| Effect of sustained inflation length on establishing functional residual capacity at birth in ventilated premature rabbits. | |
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MedLine Citation:
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PMID: 19542905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of inflation length on lung aeration pattern, tidal volumes, and functional residual capacity (FRC) immediately after birth was investigated. Preterm rabbits (28 d), randomized into four groups, received a 1-, 5-, 10-, or 20-s inflation (SI) followed by ventilation with 5 cm H2O end-expiratory pressure. Gas volumes were measured by plethysmography and uniformity of lung aeration by phase contrast x-ray imaging for 7 min. The first inspiratory volume significantly (p < 0.001) increased with inflation duration from a median (IQR) of 0.2 (0.1-3.1) mL/kg for 1-s inflation to 23.4 (19.3-30.4) mL/kg for 20-s SI. The lung was uniformly aerated, and the FRC and tidal volume fully recruited after 20-s SI. A 10-s SI caused a higher FRC (p < 0.05) at 7 min, and a 20-s SI caused a higher FRC (p < 0.05) at 20 s and 7 min than a 1- or 5-s SI. The mean (SD) time for 90% of the lung to aerate was 14.0 (4.1) s using 35 cm H2O peak inflation pressure. In these rabbits, 10- and 20-s SI increased the inspiratory volume and produced a greater FRC, and a 20-s SI uniformly aerated the lung before ventilation started. |
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Authors:
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Arjan B te Pas; Melissa Siew; Megan J Wallace; Marcus J Kitchen; Andreas Fouras; Robert A Lewis; Naoto Yagi; Kentaro Uesugi; Susan Donath; Peter G Davis; Colin J Morley; Stuart B Hooper |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric research Volume: 66 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-20 Completed Date: 2009-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 295-300 Citation Subset: IM |
Affiliation:
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Neonatal Services, Royal Women's Hospital, Parkville, Victoria 3053, Australia. a.b.te_pas@lumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / anatomy & histology, physiology* Functional Residual Capacity / physiology* Humans Inhalation / physiology* Insufflation Lung / physiology, radiography Lung Volume Measurements Plethysmography Premature Birth Rabbits Random Allocation Respiration, Artificial / adverse effects, methods* Respiratory Mechanics Tidal Volume |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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