Document Detail


Effect of suspending agents on the characteristics of some anti-inflammatory suspensions.
MedLine Citation:
PMID:  3438338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of suspending agents on the physical stability and in vitro availability of mefenamic acid, flufenamic acid, glafenine, ibuprofen and azapropazone suspensions was studied. The ulcerogenic effect of these formulated suspensions on the stomach of rats was also investigated. The results revealed that 2% veegum and 2% sorbitol gave the best formulated suspension for glafenine as compared to other formulations. On the other hand, 2% veegum, 2% sobitol and 1% avicel was found to improve the physical stability of mefenamic acid and flufenamic acid suspensions. Also, the combination of 1% veegum, 1% sorbitol and 1% algin produced excellent suspension for ibuprofen and azapropazone as compared to other combinations. The results of in vitro release data proved an optimal availability of the above mentioned formulations. In addition, significant reduction in the gastric erosions in stomach of rats was observed in all mentioned suspensions except glafenine suspension.
Authors:
F Hashem; E Ramadan; Y el-Said
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Die Pharmazie     Volume:  42     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-04-01     Completed Date:  1988-04-01     Revised Date:  2007-01-29    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  732-5     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutics, Faculty of Pharmacy, University of Mansoura, A.R.E.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / administration & dosage*,  analysis,  toxicity
Drug Stability
Drug Storage
Excipients
Gastric Mucosa / anatomy & histology,  drug effects
Rats
Suspensions
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Excipients; 0/Suspensions

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