Document Detail

Effect of surgery on the systemic inflammatory response to intermittent claudication.
MedLine Citation:
PMID:  2100988     Owner:  NLM     Status:  MEDLINE    
The hypothesis that intermittent claudication initiates a systemic inflammatory response was investigated by studying the effect of exercise on markers of neutrophil activation and vascular permeability in 25 claudicants and 10 controls. Urinary albumin excretion, previously demonstrated to reflect vascular permeability, increased significantly after exercise in claudicants and was associated with decreased neutrophil filterability and increased serum lysozyme activity. No similar exercise-induced changes were seen in controls or in claudicants after successful arterial bypass surgery. These results suggest that intermittent claudication is associated with potentially deleterious systemic manifestations that are surgically reversible.
N C Hickey; P Gosling; S Baar; C P Shearman; M H Simms
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of surgery     Volume:  77     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1990-12-27     Completed Date:  1990-12-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1121-4     Citation Subset:  AIM; IM    
Department of Surgery, Selly Oak Hospital, Birmingham, UK.
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MeSH Terms
Aged, 80 and over
Capillary Permeability / physiology
Creatinine / urine
Exercise / physiology
Inflammation / physiopathology
Intermittent Claudication / physiopathology,  surgery*
Middle Aged
Muramidase / blood
Neutrophils / physiology*
Reg. No./Substance:
60-27-5/Creatinine; EC
Comment In:
Br J Surg. 1991 Mar;78(3):378-9   [PMID:  2021863 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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