| Effect of supplementation with vitamin E on LDL oxidizability and prevention of atherosclerosis. | |
| | |
MedLine Citation:
|
PMID: 9523028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Supplementation of LDL with vitamin E is thought to protect LDL from oxidative modification and prevent the development of atherosclerosis. Large epidemiological studies have revealed that vitamin E levels in plasma are inversely correlated to the incidence of coronary heart disease. Double-blind placebo-controlled trials have reported that supplementation with vitamin E decreases the incidence of coronary events in coronary heart disease (CHD) patients. However, it is not clear how high a dose of vitamin E is needed to prevent formation of atherosclerosis. In animal studies, a diet containing 0.125% vitamin E increased its levels in plasma two-fold and prevented formation of early atherosclerotic lesions in the thoracic aorta of hypercholesterolemic rabbits. Dose-response studies in humans have reported that 400 IU/day vitamin E increased its levels in plasma two-fold and prolonged the lag time before LDL oxidation. It has been reported that oxidizability of LDL was correlated to the atherosclerotic score of coronary angiography in CHD patients. About 400 IU/day vitamin E, which increases its levels two-fold and prolongs sufficiently the lag time before LDL oxidation, might be beneficial in decreasing the individual risk of CHD. |
| | |
Authors:
|
M Suzukawa; M Ayaori; H Shige; T Hisada; T Ishikawa; H Nakamura |
Related Documents
:
|
16504648 - The independent correlation between high-density lipoprotein cholesterol and subsequent... 9552998 - Screening for hypercholesterolaemia in primary care: randomised controlled trial of pos... 1864668 - The coronary arteries of the transplanted human heart: studies of the development of di... 6637528 - Coronary arterial disease and atheromatosis in breeding sows. 846048 - A clinicopathological study on cardiac lesions in 64 cases of disseminated intravascula... 10959518 - Changing features of stent-supported primary angioplasty for acute myocardial infarctio... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: BioFactors (Oxford, England) Volume: 7 ISSN: 0951-6433 ISO Abbreviation: Biofactors Publication Date: 1998 |
Date Detail:
|
Created Date: 1998-04-23 Completed Date: 1998-04-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8807441 Medline TA: Biofactors Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 51-4 Citation Subset: IM |
Affiliation:
|
First Department of Internal Medicine, National Defense Medical College, Saitama, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arteriosclerosis / prevention & control* Coronary Disease / blood, mortality, prevention & control Humans Lipid Peroxidation / drug effects* Lipoproteins, LDL / metabolism* Rabbits Vitamin E / administration & dosage*, blood, therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Lipoproteins, LDL; 1406-18-4/Vitamin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Singlet oxygen scavenging by alpha-tocopherol and beta-carotene: kinetic studies in phospholipid mem...
Next Document: Prevention of diabetes-induced abnormal retinal blood flow by treatment with d-alpha-tocopherol.