| Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study. | |
| | |
MedLine Citation:
|
PMID: 21463230 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background. Several factors can affect oocyte quality and therefore pregnancy outcome in assisted reproductive technology (ART) cycles. Recently, a number of studies have shown that the presence of several compounds in the follicular fluid positively correlates with oocyte quality and maturation (i.e., myo-inositol and melatonin). Aim. In the present study, we aim to evaluate the pregnancy outcomes after the administration of myo-inositol combined with melatonin in women who failed to conceive in previous in vitro fertilization (IVF) cycles due to poor oocyte quality. Materials and methods. Forty-six women were treated with 4 g/day myo-inositol and 3 mg/day melatonin (inofolic® and inofolic® Plus, Lo.Lipharma, Rome) for 3 months and then underwent a new IVF cycle. Results. After treatment, the number of mature oocytes, the fertilization rate, the number of both, total and top-quality embryos transferred were statistically higher compared to the previous IVF cycle, while there was no difference in the number of retrieved oocyte. After treatment, a total of 13 pregnancies occurred, 9 of them were confirmed echographically; four evolved in spontaneous abortion. Conclusion. The treatment with myo-inositol and melatonin improves ovarian stimulation protocols and pregnancy outcomes in infertile women with poor oocyte quality. |
| | |
Authors:
|
Vittorio Unfer; Emanuela Raffone; Piero Rizzo; Silvia Buffo |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-5 |
Journal Detail:
|
Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: - ISSN: 1473-0766 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
AGUNCO Obstetrics and Gynecology Centre, via G. Cassiani, Rome, 15-00155, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hypoparathyroidism in pregnancy.
Next Document: Diagnosis of sporadic transthyretin Val30Met familial amyloid polyneuropathy: a practical analysis.