Document Detail

Effect of supplementation of limiting amino acids on tyrosine toxicity in rats fed wheat gluten diets.
MedLine Citation:
PMID:  874578     Owner:  NLM     Status:  MEDLINE    
The effect of supplementation of limiting amino acids on rats fed a 10 or 20% wheat gluten diet containing 5% tyrosine has been investigated. Growth-limiting amino acids in a 20% wheat gluten diet were lysine and threonine. When rats were fed a 20% wheat gluten diet containing excess tyrosine, the addition of 1.0% lysine-HCl or 1.0% lysine-HCl and 0.4% threonine completely prevented the development of tyrosine toxicity, and was accompanied by a lowering of free tyrosine concentrations in plasma, liver and muscle. In rats receiving a 10% wheat gluten diet, lysine, threonine and methionine were limiting for growth. The addition of 1.0% lysine-HCl to the 10% wheat gluten plus 5% tyrosine diet failed to alleviate the tyrosine toxicity, but the supplement of 1.0% lysine-HCl and 0.4% threonine could partially alleviate the toxicity. The combined addition of 1.0% lysine-HCl, 0.4% threonine and 0.5% methionine was most effective. The free tyrosine concentrations in plasma, liver and muscle were lowered greatly by the supplementation of three limiting amino acids, but amounts of free tyrosine and phenolic metabolites excreted in the urine did not decrease with addition of these limiting amino acids.
Y Yamamoto; Y Orita; K Muramatsu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  23     ISSN:  0301-4800     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  1977  
Date Detail:
Created Date:  1977-08-25     Completed Date:  1977-08-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  115-23     Citation Subset:  IM    
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MeSH Terms
Amino Acids* / pharmacology,  therapeutic use
Food, Fortified*
Liver / metabolism
Muscles / metabolism
Nutritional Requirements
Tyrosine / metabolism,  toxicity*
Reg. No./Substance:
0/Amino Acids; 55520-40-6/Tyrosine; 56-87-1/Lysine; 63-68-3/Methionine; 72-19-5/Threonine; 8002-80-0/Glutens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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