Document Detail

Effect of supplementary surfactant on in vivo lung mechanics in the premature rabbit neonate.
MedLine Citation:
PMID:  7014223     Owner:  NLM     Status:  MEDLINE    
Premature newborn rabbits, delivered on day 27 of gestation, were subjected to positive-pressure ventilation, with or without treatment with natural surfactant. The surfactant, obtained by centrifugation of lung wash from adult rabbits, was deposited in the tracheal cannula before the onset of ventilation. Parameters of lung mechanisms, recorded during spontaneous ventilation after 1 h, were significantly improved in animals receiving surfactant. In comparison with littermate controls, surfactant-treated animals also had less prominent bronchiolar epithelial lesions. We conclude that treatment with supplementary surfactant facilitates functional adaptation of the premature lung and prevents the development of epithelial lung lesions during artificial ventilation.
B Lachmann; G Grossman; R Nilsson; B Robertson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pediatrics     Volume:  136     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-07-09     Completed Date:  1981-07-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  173-9     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn
Hyaline Membrane Disease / prevention & control
Infant, Newborn
Lung / drug effects*,  pathology
Positive-Pressure Respiration
Pulmonary Surfactants / pharmacology*,  therapeutic use
Reg. No./Substance:
0/Pulmonary Surfactants

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