Document Detail

Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials.
MedLine Citation:
PMID:  12036814     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Multiple studies have been carried out to assess the effect of zinc supplementation on children's growth. The results of these studies are inconsistent, and the factors responsible for these varied outcomes are unknown. OBJECTIVE: Meta-analyses of randomized controlled intervention trials were therefore completed to assess the effect of zinc supplementation on the physical growth and serum zinc concentrations of prepubertal children. DESIGN: A total of 33 acceptable studies with appropriate data were identified by MEDLINE (National Library of Medicine, Bethesda, MD) searches and other methods. Weighted mean effect sizes (expressed in SD units) were calculated for changes in height, weight, weight-for-height, and serum zinc concentration by using random-effects models; factors associated with effect sizes were explored by meta-regression techniques. RESULTS: Zinc supplementation produced highly significant, positive responses in height and weight increments, with effect sizes of 0.350 (95% CI: 0.189, 0.511) and 0.309 (0.178, 0.439), respectively. There was no significant effect of zinc on weight-for-height indexes [weighted mean effect size: -0.018 (-0.132, 0.097)]. Zinc supplementation caused a large increase in the children's serum zinc concentrations, with an effect size of 0.820 (0.499, 1.14). Growth responses were greater in children with low initial weight-for-age z scores and in those aged >6 mo with low initial height-for-age z scores. CONCLUSIONS: Interventions to improve children's zinc nutriture should be considered in populations at risk of zinc deficiency, especially where there are elevated rates of underweight or stunting. The population mean serum zinc concentration is a useful indicator of the successful delivery and absorption of zinc supplements in children.
Kenneth H Brown; Janet M Peerson; Juan Rivera; Lindsay H Allen
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  75     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-30     Completed Date:  2002-06-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1062-71     Citation Subset:  AIM; IM    
Program in International Nutrition and the Department of Nutrition, University of California, Davis 95616, USA.
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MeSH Terms
Age Factors
Body Height / drug effects,  physiology
Body Weight / drug effects,  physiology
Child, Preschool
Dietary Supplements
Growth / drug effects*,  physiology
Infant, Newborn
Randomized Controlled Trials as Topic
Sample Size
Treatment Outcome
Zinc / administration & dosage,  blood*,  pharmacology*
Grant Support
Reg. No./Substance:
Comment In:
Am J Clin Nutr. 2002 Jun;75(6):957-8   [PMID:  12036799 ]
Natl Med J India. 2002 Sep-Oct;15(5):280-1   [PMID:  12502142 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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