Document Detail

Effect of supplemental phytonutrients on impairment of the flow-mediated brachial artery vasoactivity after a single high-fat meal.
MedLine Citation:
PMID:  12767658     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Our objective was to determine if long-term daily administration of phytonutrient supplements can prevent the immediate adverse impact of a high-fat meal and increase the production of nitric oxide. BACKGROUND: Ingestion of a high-fat meal impairs flow-mediated vasodilation of the brachial artery for at least 4 h; however, co-ingestion of vitamin antioxidants or a green salad has been shown to prevent this effect. METHODS: Flow-mediated brachial artery reactivity test (BART) both before and 3 h after a 900 calorie 50 g fat meal was evaluated in 38 healthy volunteers (age 36.4 +/- 10.1 years). Subjects were randomized to four weeks of daily supplementation with a powdered fruit vegetable juice concentrate (Juice Plus [JP]) along with a complex supplement providing nutritional antioxidants and various herbal extracts (Vineyard [V]), JP alone, or a matching placebo. At three and four weeks, BART was repeated both before and after the high-fat meal. Serum nitrate/nitrite concentrations were measured at baseline and at four weeks. RESULTS: Four weeks of the JP-V combination blunted the detrimental effect of the high-fat meal (-47.5 +/- 23.4% at baseline vs. -1.7 +/- 9.7% at four weeks [p < 0.05]). Four weeks of JP alone had a similar beneficial effect (-45.1 +/- 19.7% at baseline vs. -16.6 +/- 10.3% at four weeks [p < 0.05]), whereas there was no substantial effect of the placebo. In the subjects treated with supplements, concentrations of serum nitrate/nitrite increased from 78 +/- 39 to 114 +/- 62 microm/l (p < 0.02). CONCLUSIONS: Daily ingestion of modest amounts of a fruit/vegetable juice concentrate with or without adjunctive phytonutrient supplementation can reduce the immediate adverse impact of high-fat meals on flow-mediated vasoactivity and increase nitrate/nitrite blood concentration.
Gary D Plotnick; Mary C Corretti; Robert A Vogel; Robert Hesslink; John A Wise
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  41     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-27     Completed Date:  2003-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1744-9     Citation Subset:  AIM; IM    
Cardiology Division, University of Maryland School of Medicine, Medical Center, 22 South Greene Street, Baltimore, MD 21201, USA.
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MeSH Terms
Antioxidants / administration & dosage,  pharmacology*
Brachial Artery / physiology*
Cardiovascular Diseases / prevention & control
Cholesterol / blood
Dietary Fats / adverse effects*
Dietary Supplements*
Double-Blind Method
Endothelium, Vascular / physiology
Homocysteine / blood
Nitrates / blood
Nitric Oxide / pharmacology
Nitrites / blood
Plant Preparations / pharmacology*
Triglycerides / blood
Vitamins / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Antioxidants; 0/Dietary Fats; 0/Nitrates; 0/Nitrites; 0/Plant Preparations; 0/Triglycerides; 0/Vitamins; 10102-43-9/Nitric Oxide; 454-28-4/Homocysteine; 57-88-5/Cholesterol
Comment In:
J Am Coll Cardiol. 2003 May 21;41(10):1750-2   [PMID:  12767659 ]

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