Document Detail

Effect of sulfadiazine and pyrimethamine on selected physiologic and performance parameters in athletically conditioned thoroughbred horses during an incremental exercise stress test.
MedLine Citation:
PMID:  12050828     Owner:  NLM     Status:  MEDLINE    
Following the regimen used to treat equine protozoal myeloencephalitis, sulfadiazine (20 mg/kg) and pyrimethamine (1mg/kg) were administered orally once daily to 12 physically conditioned Thoroughbred horses for 4 consecutive days. The horses were randomly assigned to two test groups in a crossover design, with each horse serving as its own control. A stepwise exercise stress test was conducted to exhaustion. No effect on athletic performance was observed, and only marginal effects were noted in some hematologic and serochemical measurements, including decreased total white blood cell counts, red blood cell distribution width, total hemoglobin, serum sodium, and serum chloride. Serum folic acid concentration decreased significantly following sulfadiazine/pyrimethamine treatment.
Patrick T Colahan; James E Bailey; Martha Johnson; Brett L Rice; Chi-Chung Chou; Joseph P Cheeks; Galin L Jones; Mark Yang
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary therapeutics : research in applied veterinary medicine     Volume:  3     ISSN:  1528-3593     ISO Abbreviation:  Vet. Ther.     Publication Date:  2002  
Date Detail:
Created Date:  2002-06-06     Completed Date:  2002-06-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100936368     Medline TA:  Vet Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-63     Citation Subset:  IM    
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA.
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MeSH Terms
Antiprotozoal Agents / blood,  pharmacokinetics,  pharmacology*,  urine
Blood Cell Count
Blood Glucose
Creatinine / blood,  urine
Drug Therapy, Combination
Exercise Test / drug effects,  veterinary
Folic Acid / blood
Heart Rate / drug effects
Horses / physiology*
Oxygen Consumption / drug effects
Physical Conditioning, Animal / physiology*
Pyrimethamine / blood,  pharmacokinetics,  pharmacology*,  urine
Sulfadiazine / blood,  pharmacokinetics,  pharmacology*,  urine
Vitamin B 12 / blood
Reg. No./Substance:
0/Antiprotozoal Agents; 0/Blood Glucose; 58-14-0/Pyrimethamine; 59-30-3/Folic Acid; 60-27-5/Creatinine; 68-19-9/Vitamin B 12; 68-35-9/Sulfadiazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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