Document Detail

Effect of sucralfate on gastric intramucosal pH in critically ill patients.
MedLine Citation:
PMID:  9290986     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether sucralfate administration affects the tonometric measurement of gastric intramucosal pH (pHi). DESIGN: Non-randomized observational study. SETTING: General intensive care unit of a teaching hospital. PATIENTS: Twenty critically ill, mechanically ventilated, consecutively admitted patients requiring an arterial catheter and nasogastric tube. INTERVENTIONS: Tonometer placement and sucralfate administration. MEASUREMENTS AND MAIN RESULTS: We simultaneously determined tonometer saline PCO2 (PCO2i), arterial blood gases, pH of gastric juice and pHi. These parameters were evaluated immediately before sucralfate administration, and 2 h and 4 h after. We did not detect any change in either PCO2i or pHi after sucralfate administration (PCO2i: basal 6.4 +/- 1.7, 2 h 6.3 +/- 1.7, 4 h 6.3 +/- 1.7; pHi: basal 7.35 +/- 0.13, 2 h 7.36 +/- 0.12, 4 h 7.36 +/- 0.12). CONCLUSIONS: Sucralfate does not affect the tonometric measurement of PCO2i and pHi.
X Calvet; F Baigorri; M Duarte; D Joseph; P Saura; A Mas; C Royo; A Artigas
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Intensive care medicine     Volume:  23     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-10-22     Completed Date:  1997-10-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  738-42     Citation Subset:  IM    
Internal Medicine Department, Hospital de Sabadell, Barcelona, Spain.
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MeSH Terms
Analysis of Variance
Anti-Ulcer Agents* / therapeutic use
Blood Gas Analysis
Critical Illness / therapy*
Drug Monitoring
Gastric Acidity Determination
Gastric Mucosa / drug effects*
Hydrogen-Ion Concentration
Middle Aged
Respiration, Artificial
Sucralfate / therapeutic use*
Time Factors
Reg. No./Substance:
0/Anti-Ulcer Agents; 54182-58-0/Sucralfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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