| Effect of sucralfate on gastric intramucosal pH in critically ill patients. | |
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MedLine Citation:
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PMID: 9290986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether sucralfate administration affects the tonometric measurement of gastric intramucosal pH (pHi). DESIGN: Non-randomized observational study. SETTING: General intensive care unit of a teaching hospital. PATIENTS: Twenty critically ill, mechanically ventilated, consecutively admitted patients requiring an arterial catheter and nasogastric tube. INTERVENTIONS: Tonometer placement and sucralfate administration. MEASUREMENTS AND MAIN RESULTS: We simultaneously determined tonometer saline PCO2 (PCO2i), arterial blood gases, pH of gastric juice and pHi. These parameters were evaluated immediately before sucralfate administration, and 2 h and 4 h after. We did not detect any change in either PCO2i or pHi after sucralfate administration (PCO2i: basal 6.4 +/- 1.7, 2 h 6.3 +/- 1.7, 4 h 6.3 +/- 1.7; pHi: basal 7.35 +/- 0.13, 2 h 7.36 +/- 0.12, 4 h 7.36 +/- 0.12). CONCLUSIONS: Sucralfate does not affect the tonometric measurement of PCO2i and pHi. |
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Authors:
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X Calvet; F Baigorri; M Duarte; D Joseph; P Saura; A Mas; C Royo; A Artigas |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Intensive care medicine Volume: 23 ISSN: 0342-4642 ISO Abbreviation: Intensive Care Med Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1997-10-22 Completed Date: 1997-10-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 738-42 Citation Subset: IM |
Affiliation:
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Internal Medicine Department, Hospital de Sabadell, Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analysis of Variance Anti-Ulcer Agents* / therapeutic use Blood Gas Analysis Critical Illness / therapy* Drug Monitoring Female Gastric Acidity Determination Gastric Mucosa / drug effects* Humans Hydrogen-Ion Concentration Male Middle Aged Respiration, Artificial Sucralfate / therapeutic use* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 54182-58-0/Sucralfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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