| Effect of successful thrombolytic therapy on right ventricular function in acute inferior wall myocardial infarction. | |
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MedLine Citation:
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PMID: 6496358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 19 patients undergoing intracoronary fibrinolytic therapy for acute myocardial infarction, the site of coronary obstruction was in the proximal right coronary artery. Time between onset of symptoms and hospitalization was less than 4 hours. These patients were studied prospectively by radionuclide techniques immediately after admission, 48 hours and 4 weeks after AMI. Right and left ventricular (RV and LV) ejection fractions (EF) were calculated from gated blood pool scintigrams and the size of the LV perfusion defect was assessed by thallium-201 scintigraphy. Before the intervention, RV performance was significantly lower (RVEF 29 +/- 8%) than normal (53 +/- 7%). The size of the LV perfusion defect was relatively small (less than 25% of LV circumference), and as a consequence, LV pump function was only marginally impaired (LVEF 54 +/- 11%). Recanalization of the infarct artery was achieved in 12 patients (group A); in 7 patients the infarct artery remained occluded (group B). Early after the intervention (48 hours), RV performance in group A recovered significantly (RVEF: 30 +/- 9% vs 39 +/- 7%, p less than 0.01), and further improvement was noted at 4 weeks (RVEF 43 +/- 5%, p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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G Schuler; M Hofmann; F Schwarz; H Mehmel; J Manthey; H Tillmanns; S Hartmann; W Kübler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of cardiology Volume: 54 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1984 Nov |
Date Detail:
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Created Date: 1984-12-05 Completed Date: 1984-12-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 951-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Coronary Circulation Coronary Vessels / drug effects, radionuclide imaging Heart / physiopathology*, radionuclide imaging Humans Middle Aged Myocardial Infarction / drug therapy*, physiopathology, radionuclide imaging Radioisotopes / diagnostic use Streptokinase / therapeutic use* Stroke Volume / drug effects Thallium / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Radioisotopes; 7440-28-0/Thallium; EC 3.4.-/Streptokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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