Document Detail

Effect of successful thrombolytic therapy on right ventricular function in acute inferior wall myocardial infarction.
MedLine Citation:
PMID:  6496358     Owner:  NLM     Status:  MEDLINE    
In 19 patients undergoing intracoronary fibrinolytic therapy for acute myocardial infarction, the site of coronary obstruction was in the proximal right coronary artery. Time between onset of symptoms and hospitalization was less than 4 hours. These patients were studied prospectively by radionuclide techniques immediately after admission, 48 hours and 4 weeks after AMI. Right and left ventricular (RV and LV) ejection fractions (EF) were calculated from gated blood pool scintigrams and the size of the LV perfusion defect was assessed by thallium-201 scintigraphy. Before the intervention, RV performance was significantly lower (RVEF 29 +/- 8%) than normal (53 +/- 7%). The size of the LV perfusion defect was relatively small (less than 25% of LV circumference), and as a consequence, LV pump function was only marginally impaired (LVEF 54 +/- 11%). Recanalization of the infarct artery was achieved in 12 patients (group A); in 7 patients the infarct artery remained occluded (group B). Early after the intervention (48 hours), RV performance in group A recovered significantly (RVEF: 30 +/- 9% vs 39 +/- 7%, p less than 0.01), and further improvement was noted at 4 weeks (RVEF 43 +/- 5%, p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
G Schuler; M Hofmann; F Schwarz; H Mehmel; J Manthey; H Tillmanns; S Hartmann; W Kübler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  54     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1984-12-05     Completed Date:  1984-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  951-7     Citation Subset:  AIM; IM    
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MeSH Terms
Coronary Circulation
Coronary Vessels / drug effects,  radionuclide imaging
Heart / physiopathology*,  radionuclide imaging
Middle Aged
Myocardial Infarction / drug therapy*,  physiopathology,  radionuclide imaging
Radioisotopes / diagnostic use
Streptokinase / therapeutic use*
Stroke Volume / drug effects
Thallium / diagnostic use
Reg. No./Substance:
0/Radioisotopes; 7440-28-0/Thallium; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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