| Effect of substance P and its C-terminal hexapeptide on gastric and pancreatic secretion in the dog. | |
| | |
MedLine Citation:
|
PMID: 6166208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In five dogs with gastric fistulas, Heidenhain pouches, and pancreatic fistulas, the effects of substance P (SP) and its C-terminal hexapeptide (SP6-11) on gastric acid and pancreatic secretions were determined under basal conditions and in response to secretory stimulation. SP or SP6-11 infused alone in graded doses (0.25-2.0 nmol.kg-1.h-1) caused a slight but significant increase in pancreatic secretions in fasted dogs, but, when given during the secretory stimulation, they caused significant inhibition of these secretions. They reduced gastric acid response to pentagastrin and peptone meal without affecting the serum gastrin level. They caused dose-dependent inhibition of secretin-induced pancreatic bicarbonate secretion and suppressed the pancreatic protein response to caerulein, feeding, and duodenal acidification. SP6-11 was equipotent on a molar basis with SP in the inhibition of gastric or pancreatic secretion, indicating that the C-terminal portion of SP exhibits a full spectrum of the biological action of the intact molecule. The inhibitory effects of SP and SP6-11 on the stomach and pancreas were observed at a dose range that was without any significant influence on the blood pressure, indicating that they are not caused by the interference of the blood flow to the pancreas. |
| | |
Authors:
|
S J Konturek; J Jaworek; J Tasler; M Cieszkowski; W Pawlik |
Related Documents
:
|
6108678 - Oxygen supply, oxygen consumption, and endocrine and exocrine secretions of the isolate... 22441618 - Vascular occlusion or not during liver resection: the continuing story. 21952728 - Hydrodynamic focusing-a versatile tool. 988548 - Hemodynamic effects of norepinephrine and isoprenaline in various regions of the canine... 1388228 - Toxicological estimate of polyvinyl chloride containers for preparation and storage of ... 14759088 - Dynamics of cutaneous laser doppler flux with concentration of moving blood cells and b... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of physiology Volume: 241 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1981 Jul |
Date Detail:
|
Created Date: 1981-08-27 Completed Date: 1981-08-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: G74-81 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bicarbonates / metabolism Blood Pressure / drug effects Dogs Dose-Response Relationship, Drug Duodenum / physiology Gastric Juice / drug effects, secretion* Heart Rate / drug effects Hydrogen-Ion Concentration Kinetics Pancreatic Juice / drug effects, secretion* Peptide Fragments / pharmacology* Proteins / secretion Pyrrolidonecarboxylic Acid / analogs & derivatives Substance P / analogs & derivatives*, pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Bicarbonates; 0/Peptide Fragments; 0/Proteins; 33507-63-0/Substance P; 51165-07-2/substance P (6-11); 98-79-3/Pyrrolidonecarboxylic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Digestive end products mobilize secretory proteins from subcellular stores in the pancreas.
Next Document: Developmental structuralist approach to the classification of adaptive and pathologic personality or...