Document Detail


Effect of subordinance, lack of social hierarchy, and restricted feeding on murine survival and virus leukemia.
MedLine Citation:
PMID:  1756779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When caged in groups of three and fed ad libitum, dominant male mice survived longer than subordinate group members which again lived longer than males caged in groups of nine, among whom no rank order was established. In groups of nine the social structure was not affected when the food supply was reduced to the lowest level not affecting survival, but in groups of three, food reduction made the survival of both dominant and subordinate animals drop to a level matching that of groups of nine. After challenge with a small dose of Moloney virus, leukemia developed among ad libitum fed subordinate mice in groups of three and members of groups of nine, but not among the dominant animals. Food restriction enhanced the leukemia incidence, but dominant animals continued to go free. We conclude that subordinance and also lack of social hierarchy result in a higher incidence of virus induced leukemia, that severe food restriction does the same, and that the effect of social order on leukemia development prevails even under feeding conditions that nearly abolish group-related differences in survival.
Authors:
P Ebbesen; J A Villadsen; H D Villadsen; K E Heller
Related Documents :
7666259 - Pre- and postweaning food restrictions interact to determine reproductive success and m...
8580879 - Energy balance of rats subjected to continuous and intermittent food restriction.
106089 - The relationship between energy-dependent phagocytosis and the rate of oxygen consumpti...
2578559 - Loss of tissues in female rats subjected to food restriction during lactation or during...
18729649 - Galanin stimulation of feeding is blocked by the addition of a response requirement.
1281699 - Glucocorticoid treatment or food deprivation counteract the stimulating effect of growt...
17787469 - Ecology and acculturation among native peoples of central brazil.
18479779 - Modeling of palatable food intake in female young adults. effects of perceived body size.
11999789 - Spatial distribution of polybrominated diphenyl ethers and polybrominated biphenyls in ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental gerontology     Volume:  26     ISSN:  0531-5565     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  1991  
Date Detail:
Created Date:  1992-02-03     Completed Date:  1992-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  479-86     Citation Subset:  IM    
Affiliation:
Department of Virus and Cancer, Danish Cancer Society, Aarhus.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal
Disease Susceptibility
Food Deprivation*
Hierarchy, Social*
Leukemia, Experimental / etiology*
Male
Mice
Mice, Inbred DBA
Moloney murine leukemia virus*
Mortality*
Social Dominance*
Social Isolation
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Individual variability in tail tendon fiber break time in three age cohorts of different strains of ...
Next Document:  Ascorbic acid in Drosophila and changes during aging.