Document Detail


Effect of subcutaneous sumatriptan, a selective 5HT1 agonist, on the systemic, pulmonary, and coronary circulation.
MedLine Citation:
PMID:  8381056     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sumatriptan (GR43175) is a selective 5-hydroxytryptamine (5HT1) receptor agonist effective in the acute treatment of migraine. Recent in vitro experiments suggest that it has vasoactive properties in vascular beds distinct from the cerebral circulation. The object of this study was to assess the vasoactive effects of the standard 6-mg subcutaneous dose of sumatriptan used in migraine on the systemic and pulmonary circulations and the coronary artery vasculature. METHODS AND RESULTS: Ten patients undergoing diagnostic coronary arteriography were studied with digital subtraction angiography and invasive hemodynamic monitoring. After subcutaneous injection of sumatriptan, there was no significant change in heart rate or ECG morphology. There was a significant rise in the systemic (20%, p < 0.05 by ANOVA) and pulmonary artery (40%, p < 0.05 by ANOVA) pressures. There was no change in cardiac output, but there was a significant increase in total systemic (27%, p < 0.05) and total pulmonary vascular resistance (40%, p < 0.05). Sumatriptan caused a significant reduction (p < 0.001 by ANOVA) in mean absolute coronary artery diameter, from 4.36 +/- 1.60 mm at baseline to 3.67 +/- 1.49 mm (16%) at 10 minutes and to 3.63 +/- 1.49 mm (17%) at 30 minutes after injection. There were no clinical sequelae. CONCLUSIONS: Sumatriptan, a 5HT1 receptor agonist administered by the subcutaneous route, causes a vasopressor response in the systemic and pulmonary arterial circulations and coronary artery vasoconstriction.
Authors:
P D MacIntyre; B Bhargava; K J Hogg; J D Gemmill; W S Hillis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  87     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-03     Completed Date:  1993-03-03     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  401-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine and Therapeutics, University of Glasgow, Scotland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Circulation / drug effects*
Coronary Circulation / drug effects*
Coronary Vessels / drug effects
Female
Hemodynamics / drug effects
Humans
Indoles / blood,  pharmacology*
Injections, Subcutaneous
Male
Middle Aged
Pulmonary Circulation / drug effects*
Reproducibility of Results
Sulfonamides / blood,  pharmacology*
Sumatriptan
Vasoconstrictor Agents / pharmacology
Chemical
Reg. No./Substance:
0/Indoles; 0/Sulfonamides; 0/Vasoconstrictor Agents; 103628-46-2/Sumatriptan

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