Document Detail


Effect of subacute administration of isoniazid and pyridoxine on lipids in plasma, liver and adipose tissues in the rabbit.
MedLine Citation:
PMID:  1935708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of subacute intraperitoneal administration of Isoniazid (INH) on various lipid parameters was studied in liver and adipose tissue in addition to plasma. In the liver, its effect on various phospholipid fractions was also assessed. The changes in lipid profile reflected INH-induced hepatic steatosis. While pyridoxine alone did not alter any of these lipid parameters, its concurrent administration with INH prevented almost all the INH-induced lipid changes. The enhanced lipid mobilization into liver, and a fall in phosphatidylcholine with a concomitant rise in phosphatidylethanolamine in liver impeding lipoprotein synthesis, might be responsible for the hepatic steatosis. Pyridoxal, a pyridoxine metabolite, might have trapped the primary amine functional group of acetylhydrazine and thus prevented the steatosis.
Authors:
S Karthikeyan; M S Krishnamoorthy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug and chemical toxicology     Volume:  14     ISSN:  0148-0545     ISO Abbreviation:  Drug Chem Toxicol     Publication Date:  1991  
Date Detail:
Created Date:  1991-11-25     Completed Date:  1991-11-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7801723     Medline TA:  Drug Chem Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  293-303     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Environmental Toxicology, University of Madras, India.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / chemistry,  drug effects*
Animals
Female
Isoniazid / toxicity*
Lipids / analysis*
Liver / chemistry,  drug effects*
Male
Pyridoxine / pharmacology*
Rabbits
Chemical
Reg. No./Substance:
0/Lipids; 54-85-3/Isoniazid; 65-23-6/Pyridoxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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