Document Detail

Effect of strontium on the epiphyseal cartilage plate of rat tibiae-histological and radiographic studies.
MedLine Citation:
PMID:  1021603     Owner:  NLM     Status:  MEDLINE    
Following dietary administration of strontium carbonate, histological and radiographic changes in the epiphyseal cartilage plate of the rat tibiae were examined in the present study. The weight gain of the rat fed a strontium diet was less than that of the control rats. Longitudinal growth of tibiae and endochondral ossification were inhibited by strontium administration. The widths of both proximal and distal cartilage plates increased enormously as has also been shown by other investigators. Sizes of chondroblasts in columns of proximal cartilage plate in rats fed a strontium diet were smaller than those of the control rats and were not different between upper and lower parts. It is suggested that strontium inhibits bone growth through the inhibitory action on the maturation process of chondroblasts and the succeeding endochondral ossification.
A Matsumoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  26     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1976 Dec 
Date Detail:
Created Date:  1977-05-12     Completed Date:  1977-05-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  675-81     Citation Subset:  IM    
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MeSH Terms
Body Weight / drug effects
Cartilage / anatomy & histology,  drug effects*,  radiography
Epiphyses / anatomy & histology,  drug effects*,  radiography
Osteogenesis / drug effects
Strontium / pharmacology*
Time Factors
Reg. No./Substance:

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