Document Detail


Effect of stress induced by electrical stimulation of the hypothalamus on the electrical stability of the heart in rabbits.
MedLine Citation:
PMID:  15764016     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of stress on cardiac electrical stability (CES) and chaotic dynamics of the electrical activity of the heart was studied in acute and chronic experiments in rabbits. Stress was caused by 2-3 h daily immobilization of the animals with electrical stimulation of emotiogenic centers of the hypothalamus through implanted electrodes. CES was estimated by the thresholds for ventricular arrhythmia: paroxysmal ventricular tachycardia, repeated ventricular extrasystoles and ventricular fibrillation (VF). The results showed: (i) CES in stressed rabbits was decreased significantly compared with controls; (ii) the level of chaos at the onset of VF in stressed rabbits was increased significantly compared with controls; (iii) heart rate of stressed rabbits was significantly greater than in controls; (iv) changes in CES parameters depended on whether stress was acute or chronic; (v) acute stress promoted transition of spontaneously reversible VF into spontaneously irreversible VF. Thus, stress increased the degree of disorganization of heart electrical activity and also decreased its electrical stability. The experiments indicate that stress is a destabilizing factor influencing the reversibility of heart rate disorders. The probability of such reversibility depends on whether stress is acute or chronic: acute stress is more likely to lead to irreversible spontaneous VF.
Authors:
Sergei I Kashtanov; Larisa V Mezentseva; Marina A Zvyagintseva; Irina L Kosharskaja; Konstantin V Sudakov
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stress (Amsterdam, Netherlands)     Volume:  7     ISSN:  1025-3890     ISO Abbreviation:  Stress     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2005-03-14     Completed Date:  2005-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9617529     Medline TA:  Stress     Country:  England    
Other Details:
Languages:  eng     Pagination:  189-94     Citation Subset:  IM    
Affiliation:
P.K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Mokhovaya street 11, corpus 4, 125009 Moscow, Russia.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Affective Symptoms / physiopathology
Animals
Chronic Disease
Electric Stimulation / methods*
Heart Conduction System / physiology*
Heart Rate / physiology
Hypothalamus / physiology*
Male
Nonlinear Dynamics
Rabbits
Restraint, Physical
Stress, Psychological / physiopathology*
Ventricular Fibrillation / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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