| Effect of stimulus size on static visual fields in patients with retinitis pigmentosa. | |
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MedLine Citation:
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PMID: 11013205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine the effect of stimulus size on sensitivity of patients with retinitis pigmentosa (RP) as measured by automated static perimetry. DESIGN: Comparative case series. PARTICIPANTS: Thirty-nine patients with RP and a control group of 10 healthy volunteers. METHODS: Automated static perimetry (full threshold programs 24-2 or 30-2) was performed twice on one eye of each participant using stimulus sizes III (0.43 degrees diameter) and V (1.72 degrees diameter). Data from the same 50 test locations were used from each field. MAIN OUTCOME MEASURES: At each location, for each participant, the size effect was computed as the difference (in decibels) in sensitivities for sizes V and III, and the average sensitivity was computed as the mean of sensitivities for the two sizes. RESULTS: For both patient and control groups, the size effect was negatively correlated with average sensitivity (r(2) > 0.124; P: < 0.001). The mean size effect was significantly greater for the patient group than for the control group: 8.6 (+/- 3.6) dB versus 5. 4 (+/- 2.2) dB (t = 18.0; P: < 0.001). The percentage of abnormal locations (more than 8 dB below mean normal) tended to be lower for size V than for size III, with a mean of 67% for size V versus 95% for size III. The percentage of absolute defects was also lower for size V than for size III, with a mean of 35% for size V versus 54% for size III. CONCLUSIONS: In damaged regions of the visual fields of patients with RP, increase in stimulus size from III to V can produce abnormally large increases in perimetric sensitivity. Size III may be more useful than size V for detection of field abnormality, whereas size V may be more useful than size III for observing progression of advanced RP. |
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Authors:
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W H Swanson; J Felius; D G Birch |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Ophthalmology Volume: 107 ISSN: 0161-6420 ISO Abbreviation: Ophthalmology Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-10-17 Completed Date: 2000-10-17 Revised Date: 2012-06-26 |
Medline Journal Info:
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Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1950-4 Citation Subset: IM |
Affiliation:
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Retina Foundation of the Southwest, Dallas, Texas, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Retina / physiopathology* Retinitis Pigmentosa / genetics, physiopathology* Sensitivity and Specificity Visual Field Tests / methods* Visual Fields / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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EY05235/EY/NEI NIH HHS; EY07716/EY/NEI NIH HHS; R01 EY007716/EY/NEI NIH HHS; R01 EY007716-09/EY/NEI NIH HHS; R01 EY007716-10/EY/NEI NIH HHS |
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