Document Detail


Effect of sterol structure on the transfer of sterols and phospholipids from liposomes to erythrocytes in vitro.
MedLine Citation:
PMID:  7104375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human erythrocytes were incubated for 24 h with liposomes containing [3H]phosphatidylcholine, [14C]cholesterol and one of several other sterols. Of the other sterols, 3-hydroxycholest-3-en-2-one did not appear to be taken up by the cells, sterophenol was taken up at about the same rate as cholesterol, and cholesta-4,6-dien-3-one and 7-oxocholesterol were taken up much more rapidly than cholesterol. Each component of the liposomes was incorporated into the cells independently of the others and the rate of incorporation of the test sterol had little, if any, effect on the rate of incorporation of phospholipid or cholesterol. The results support the proposal that sterol exchange is mediated via the pool of monomers present in the medium rather than by a collision mechanism.
Authors:
S A Wharton; C Green
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  711     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-10-29     Completed Date:  1982-10-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  398-402     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cholestenones / metabolism
Cholesterol / metabolism
Erythrocytes / metabolism*
Humans
Ketocholesterols / metabolism
Kinetics
Liposomes / metabolism*
Phosphatidylcholines / metabolism*
Sterols / metabolism*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Cholestenones; 0/Ketocholesterols; 0/Liposomes; 0/Phosphatidylcholines; 0/Sterols; 566-93-8/4,6-cholestadien-3-one; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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