| [Effect of steroids on the formation of progesterone in the fetal membrane]. | |
| | |
MedLine Citation:
|
PMID: 3160795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Recently, there have been some reports on the capacity of steroid metabolism of the fetal membrane. However, the mechanism of its regulation and its physiological meaning are not known. The authors therefore studied the progesterone (P4) producing capacity of the membrane and the effects of various types of sex steroids on it, using membrane cells. The membranes collected at the times of normal transvaginal deliveries (labor pains (+) group) and elective cesarean sections (labor pains (-) group) were separated into the decidua (D), chorion (C) and amnion (A), and were treated with collagenase to form free membrane cells. They were then incubated and studied for the conversion of pregnanolone (P5) which was added into P4 as a substrate. The effects of estradiol (E2), dehydroepiandrosterone (DHA) and testosterone (T) on the conversion were also studied. The following results were obtained: 1) In the labor pain (+) group, C, D and A demonstrated the capacity to convert P5. The conversions in C and D were linearly dose-responsive in the P5 dose ranges of 0-1,000 ng/ml and 100-1,000 ng/ml, respectively. By contrast, there was no linear dose-response relationship in the conversion in A. 2) The production of P4 in C was significantly inhibited by the addition of E2, DHA and T. 3) The production of P4 in A and D was not affected by other steroids. 4) In the labor pain (-) group, the production of P4 in C was not inhibited by E2 and DHA.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
D Hori |
Publication Detail:
|
Type: English Abstract; Journal Article |
Journal Detail:
|
Title: Nihon Sanka Fujinka Gakkai zasshi Volume: 37 ISSN: 0300-9165 ISO Abbreviation: Nippon Sanka Fujinka Gakkai Zasshi Publication Date: 1985 Jun |
Date Detail:
|
Created Date: 1985-09-19 Completed Date: 1985-09-19 Revised Date: 2011-07-29 |
Medline Journal Info:
|
Nlm Unique ID: 7505749 Medline TA: Nihon Sanka Fujinka Gakkai Zasshi Country: JAPAN |
Other Details:
|
Languages: jpn Pagination: 982-90 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cells, Cultured Cesarean Section Dehydroepiandrosterone / physiology* Estradiol / physiology* Extraembryonic Membranes / metabolism* Female Humans Labor, Obstetric Pregnancy Pregnenolone / metabolism Progesterone / biosynthesis* Testosterone / physiology* |
| Chemical | |
Reg. No./Substance:
|
145-13-1/Pregnenolone; 50-28-2/Estradiol; 53-43-0/Dehydroepiandrosterone; 57-83-0/Progesterone; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Induction and suppression of contact sensitivity to fluorescein isothiocyanate (FITC).
Next Document: Fetal abnormality (Goldenhar syndrome) occurring in one of triplet infants derived from in vitro fer...