Document Detail

Effect of steroidal and non-steroidal anti-inflammatory drugs in combination with long-acting oxytetracycline on non-specific immunity of calves suffering from enzootic bronchopneumonia.
MedLine Citation:
PMID:  14516708     Owner:  NLM     Status:  MEDLINE    
The aim of this paper was to compare the effect of flumethasone and meloxicam in combination with oxytetracycline on clinical and immunological parameters of calves suffering from enzootic bronchopneumonia. The study was performed on 30 Black-and-White Lowland Breed calves with clinical signs of enzootic bronchopneumonia divided randomly into three equal groups and, respectively, treated with-Group I: oxytetracycline and meloxicam; Group II: oxytetracycline and flumethasone; Group III (control): oxytetracycline only. Treatment of calves with the combination of oxytetracycline and meloxicam (Group I) caused a significantly faster, in comparison to other groups, improvement in the clinical illness index score (CIIS: cough, nasal discharge, dyspnea, depression and anorexia) and a faster normalization of body temperature. A slow decrease in white blood cell (WBC) count, the number of neutrophils, MID (mixed number of monocytes, eosinophils and basophils) and in the individual number of monocytes (CD14/CD45 positive cells) was observed in Groups I and III. In the blood of the calves which received oxytetracycline and flumethasone (Group II), leukocytosis, neutrophilia and monocytosis with concomitant lymphopenia and a low number of T cells (CD2+) was observed. Moreover, the calves treated with flumethasone exhibited a decrease in gamma-globulin concentration, and phagocytic parameters. Both drugs, flumethasone and meloxicam slightly decreased tumor necrosis factor (TNF) but meloxicam slightly increased the levels of interferon (IFN) in sera and in bronchoalveolar lavages (BALs). These results suggest that the combination of meloxicam with an antibiotic in calves suffering from enzootic bronchopneumonia is superior to the antibiotic alone and also to the combination of the antibiotic with flumethasone.
Dariusz Bednarek; Barbara Zdzisińska; Marian Kondracki; Martyna Kandefer-Szerszeń
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary microbiology     Volume:  96     ISSN:  0378-1135     ISO Abbreviation:  Vet. Microbiol.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-30     Completed Date:  2004-01-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7705469     Medline TA:  Vet Microbiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  53-67     Citation Subset:  IM    
Department of Cattle and Sheep Diseases, National Veterinary Research Institute, Partyzantów 57, 24-100, Pulawy, Poland.
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MeSH Terms
Animals, Newborn
Anti-Bacterial Agents / therapeutic use*
Anti-Inflammatory Agents / therapeutic use*
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Bronchoalveolar Lavage Fluid / cytology,  immunology
Bronchopneumonia / drug therapy,  immunology,  microbiology,  veterinary*
Cattle / immunology*
Cattle Diseases / drug therapy*,  immunology,  microbiology
Drug Therapy, Combination
Flumethasone / therapeutic use
Interferons / blood
Oxytetracycline / therapeutic use*
Phagocytosis / drug effects
Random Allocation
Thiazines / therapeutic use
Thiazoles / therapeutic use
Treatment Outcome
Tumor Necrosis Factor-alpha / metabolism
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Inflammatory Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Thiazines; 0/Thiazoles; 0/Tumor Necrosis Factor-alpha; 2135-17-3/Flumethasone; 71125-38-7/meloxicam; 79-57-2/Oxytetracycline; 9008-11-1/Interferons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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