| Effect of sternotomy and extracorporeal circulation on pulmonary neutrophil kinetics in pigs. | |
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MedLine Citation:
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PMID: 16369728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary margination of neutrophils may contribute to lung damage after extracorporeal circulation for cardiac surgery. We evaluated single-pass pulmonary neutrophil kinetics using the multiple indicator-dilution technique in control pigs (n = 10), after sternotomy alone (sterno, n = 10) or after 30 min of observation following a period of 90 min extracorporeal circulation (n = 7). Blood neutrophils increased in the control and sterno groups (p < 0.05) but remained unchanged in the extracorporeal circulation group. The transfer coefficient for neutrophil margination from the circulating to the lung-marginated pool (k(c-m)) and pulmonary neutrophil clearance (Cl(c-m)) were similar between the three groups. There was an inverse correlation between k(c-m) and the degree of lung tissue perfusion evaluated from the tracer-accessible extravascular lung water (r = -0.54, p < 0.01). There was no arterio-venous gradient of neutrophils in any of the groups, suggesting a dynamic equilibrium of the margination/demargination processes. We conclude that extracorporeal circulation does not significantly modify single pass pulmonary neutrophil kinetics 30 min after reperfusion. The rate of neutrophil margination to the tracer-accessible lung tissue suggests that lung tissue de-recruitment is associated with increased neutrophil margination. |
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Authors:
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Agnés Salamand; Andreas J Schwab; Yahye Merhi; Louis P Perrault; André Simard; Jocelyn Dupuis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-12-23 |
Journal Detail:
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Title: Basic research in cardiology Volume: 101 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-16 Completed Date: 2006-06-09 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: Germany |
Other Details:
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Languages: eng Pagination: 133-9 Citation Subset: IM |
Affiliation:
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Department of Cardiology, CHU of Timone Saint-Pierre St., 13385, Marseille, Cedex, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Adhesion / immunology Extracorporeal Circulation / adverse effects* Lung / immunology* Neutrophil Infiltration / immunology Neutrophils* Sternum / surgery* Swine |
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