| Effect of statins on serum apolipoprotein j and paraoxonase-1 levels in patients with ischemic heart disease undergoing coronary angiography. | |
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MedLine Citation:
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PMID: 18403458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been proposed that apolipoprotein J (apo J) and paraoxonase-1 (PON1) correlate with the extent and severity of ischemic heart disease (IHD). This article compares apo J and PON1 serum concentrations, PON1 activity, and the apo J/PON1 ratio in 138 IHD patients (64 statins users and 74 statin nonusers) referred for angiography and possible percutaneous coronary intervention. The effect of statin treatment on apo J and PON1 concentrations, PON1 activity, and the degree of coronary artery stenosis were evaluated. In both groups, apo J levels were increased, whereas PON1 concentration and activity decreased. IHD patients on statins had significantly lower apo J concentration and higher PON1 concentration and activity. Patients on statins had less coronary artery stenosis. High apo J levels, low PON1 levels, low PON1 activity, and a high apo J/PON1 ratio were associated with IHD. Statin treatment reverses these changes, probably by multiple beneficial actions. |
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Authors:
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Maria V Poulakou; Kosmas I Paraskevas; Ioannis S Vlachos; Sonia-Athena P Karabina; Mark R Wilson; Dimitrios C Iliopoulos; Serafim I Tsitsilonis; Dimitri P Mikhailidis; Despina N Perrea |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Angiology Volume: 59 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 2008 Apr-May |
Date Detail:
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Created Date: 2008-04-11 Completed Date: 2008-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
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Languages: eng Pagination: 137-44 Citation Subset: IM |
Affiliation:
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National and Kapodistrian University of Athens, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Aryldialkylphosphatase / blood*, drug effects Clusterin / blood*, drug effects Coronary Angiography Coronary Stenosis / blood, drug therapy, radiography Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Male Middle Aged Myocardial Ischemia / blood, drug therapy*, radiography Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/CLU protein, human; 0/Clusterin; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; EC 3.1.8.1/Aryldialkylphosphatase; EC 3.1.8.1/PON1 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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