Document Detail


Effect of statin treatment on coronary plaque progression - A serial coronary CT angiography study.
MedLine Citation:
PMID:  24267226     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVES: Statins have been shown to reduce plaque progression using data on intravascular ultrasound, carotid intima-media thickness and coronary artery calcium scans. However, there is little data on effects of statins on plaque progression using Coronary CTA. The objective is to evaluate the effect of statin therapy on plaque progression using serial Coronary CTA (CCTA).
METHODS: The study included 100 consecutive patients who underwent serial Coronary CTA (mean follow up: 406 ± 92 days) for evaluation of CAD without known prior heart disease or revascularization. We performed volumetric assessment of low attenuation plaque (LAP < 30 Hounsfield units), non-calcified (NCP) and calcified plaque volumes at baseline and follow up scans for vessels >2 mm in diameter. Patients who received statins were compared to those that did not.
RESULTS: Total plaque progression was significantly reduced among statin user compared to non-statin users (-33.3 mm(3) ± 90.5 vs. 31.0 mm(3) ± 84.5, p = 0.0006). Statin users had significantly reduced progression of NCP volume (-47.7 mm(3) ± 71.9 vs. 13.8 mm(3) ± 76.6, p < 0.001) and significantly reduced progression of LAP volume (-12.2 mm(3) ± 19.2 vs. 5.9 mm(3) ± 23.1, p < 0.0001). When we compared for remodeling index, no statistical difference was found between the two groups (p = 0.25) and a non-significant trend toward calcium progression (29.3 mm(3) ± 67.9 vs. 10.0 mm(3) ± 53.2, p = 0.133). After adjustment for cardiovascular risk factors, mean plaque volume difference between statin and non-statin users was statistically significant for both LAP and NCP volumes (-18.1, 95% CI: -26.4, -9.8 for LAP; -101.7, 95% CI: -162.1, -41.4 for NCP; p < 0.001) respectively.
CONCLUSION: Statin therapy resulted in significantly lower progression of LAP and NCP plaques compared to non-statin users.
Authors:
Irfan Zeb; Dong Li; Khurram Nasir; Jennifer Malpeso; Aisha Batool; Ferdinand Flores; Christopher Dailing; Ronald P Karlsberg; Matthew Budoff
Related Documents :
3675246 - Acute confusional state and acute agitated delirium. occurrence after infarction in the...
16278856 - Rates of cerebral atrophy in autopsy-confirmed progressive supranuclear palsy.
9822126 - Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (melas...
16979066 - Carotid vulnerable lesions are related to accelerated recurrence for cerebral infarctio...
1555476 - The diagnosis of acute myocardial infarction.
3444036 - Long-term prognosis of vasospastic angina without significant atherosclerotic coronary ...
Publication Detail:
Type:  Journal Article     Date:  2013-08-29
Journal Detail:
Title:  Atherosclerosis     Volume:  231     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-11-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  198-204     Citation Subset:  IM    
Copyright Information:
Copyright © 2013. Published by Elsevier Ireland Ltd.
Affiliation:
Department of Medicine, Bronx-Lebanon Hospital Center, USA. Electronic address: izeb82@gmail.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Association of obstructive sleep apnoea with subclinical coronary atherosclerosis.
Next Document:  Genetic and environmental effects on carotid flow velocities: An international twin study.