Document Detail

Effect of statin therapy on risk of ventricular arrhythmia among patients with coronary artery disease and an implantable cardioverter-defibrillator.
MedLine Citation:
PMID:  15695135     Owner:  NLM     Status:  MEDLINE    
Hydroxymethylglutaryl coenzyme-A reductase inhibitors, or statins, have been shown to decrease mortality rates in patients who have coronary artery disease. It has been postulated that part of the mortality benefit conferred by statins is due to a decrease in ventricular arrhythmias. We assessed the effect of statin therapy on recurrent ventricular arrhythmias in 281 patients who developed coronary artery disease after implantable cardioverter-defibrillator placement. Statin therapy was associated with a significant decrease in the risk of ventricular arrhythmia that would require implantable cardioverter-defibrillator therapy.
John H Chiu; Raed H Abdelhadi; Mina K Chung; Hitinder S Gurm; Nassir F Marrouche; Walid I Saliba; Andrea Natale; David O Martin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  95     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-07     Completed Date:  2005-04-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  490-1     Citation Subset:  AIM; IM    
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.
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MeSH Terms
Coronary Artery Disease / therapy*
Defibrillators, Implantable*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Proportional Hazards Models
Recurrence / prevention & control
Retrospective Studies
Risk Factors
Ventricular Fibrillation / therapy*
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors
Comment In:
Am J Cardiol. 2006 Jan 1;97(1):153-4   [PMID:  16377305 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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