| Effect of starch 1500 as a binder and disintegrant in lamivudine tablets prepared by high shear wet granulation. | |
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MedLine Citation:
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PMID: 18930870 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High shear wet granulation is a preferred manufacturing method of tablets. It allowed for rapid production of compressible granulations. The resultant granulation characteristics depend on a combination of formulation properties and processing parameters. Fully pregelatinized starches are currently being used as binders in wet granulated formulations. But due to the gelatinization, much of the disintegration properties are lost. Partially pregelatinized starches (starch 1,500) have a mixture of properties of both native and fully gelatinized starches; made them useful as both a binder and a disintegrant in wet granulated formulations. Starch 1,500 performed as an excellent binder producing a granulation that was compressible and produced lamivudine tablets of improved hardness and friability compared with those prepared with povidone. The formulation of lamivudine tablets with starch 1,500 exceeded the disintegration and dissolution performance of the povidone formulation that utilized a super disintegrant. High shear wet granulation is also well suited for the use of partially pregelatinized starches. |
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Authors:
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Bytul M Rahman; Mir Imam Ibne-Wahed; Proma Khondkar; Maruf Ahmed; Robiul Islam; Ranjan K Barman; M Anwarul Islam |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pakistan journal of pharmaceutical sciences Volume: 21 ISSN: 1011-601X ISO Abbreviation: Pak J Pharm Sci Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2008-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426356 Medline TA: Pak J Pharm Sci Country: Pakistan |
Other Details:
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Languages: eng Pagination: 455-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chemistry, Pharmaceutical Drug Compounding Excipients / chemistry* Gelatin / chemistry* Hardness Lamivudine / chemistry* Particle Size Povidone / chemistry Reverse Transcriptase Inhibitors / chemistry* Solubility Starch / analogs & derivatives*, chemistry* Tablets Technology, Pharmaceutical / methods* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Excipients; 0/Reverse Transcriptase Inhibitors; 0/Tablets; 134678-17-4/Lamivudine; 9000-70-8/Gelatin; 9003-39-8/Povidone; 9005-25-8/Starch; 9063-38-1/sodium starch glycolate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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