Document Detail

Effect of a standard test meal on serum bile acid levels in healthy nonpregnant and pregnant women and in patients with intrahepatic cholestasis of pregnancy.
MedLine Citation:
PMID:  6667014     Owner:  NLM     Status:  MEDLINE    
Eight healthy nonpregnant women, nine pregnant women, and eight patients with intrahepatic cholestasis (IHC) of pregnancy were investigated. Serum samples were collected after overnight fasting just before the application of the test meal and 30, 60, 120 and 180 min afterwards for determination of serum cholic acid (CA), chenodeoxycholic acid (CDCA) and deoxycholic acid (DCA) concentrations by radioimmunoassays. After the test meal primary bile acid levels were increased significantly (p less than 0.01) in every group after one hour and CDCA concentrations increased to a greater extent and more rapidly than those of CA. In pregnant women there were two cases with increased CA levels after three hours. In patients with IHC of pregnancy CA concentrations after three hours were higher than the initial fasting levels in every case and also over the normal reference limit. The testing of liver function by measuring the serum concentrations of endogenous bile acids after the test meal seems to be useful and more sensitive than measuring the levels of fasting bile acids in the mild forms of IHC of pregnancy. Normal pregnancy also appears to result in a somewhat cholestatic condition.
J Heikkinen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical research     Volume:  15     ISSN:  0003-4762     ISO Abbreviation:  Ann. Clin. Res.     Publication Date:  1983  
Date Detail:
Created Date:  1984-03-21     Completed Date:  1984-03-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0220042     Medline TA:  Ann Clin Res     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  183-8     Citation Subset:  IM    
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MeSH Terms
Bile Acids and Salts / blood*
Cholestasis, Intrahepatic / blood*
Pregnancy Complications / blood*
Reg. No./Substance:
0/Bile Acids and Salts

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