| Effect of splenectomy on reticuloendothelial function and survival following sepsis. | |
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MedLine Citation:
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PMID: 7401204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is well known that splenectomy causes immunologic impairment and increases susceptibility to infection; however, the time course of reticuloendothelial depression and of alterations in hepatic and pulmonary retention of injected lipid emulsion following splenectomy is not known. To determine this, rats were splenectomized and reticuloendothelial function evaluated at various intervals following splenectomy by measuring the intravascular clearance of 131I-triolein gelatinized lipid emulsion. The intravascular clearance (T/2) and lung uptake of the lipid emulsion increased and hepatic uptake of emulsion decreased 4 to 8 hours following splenectomy. One day followng splenectomy, although the T/2 appeared normal, the lung uptake was 1,123% higher and hepatic uptake was still 33% lower than control. The T/2 and hepatic retention returned to normal 2 days following splenectomy; however, the lung retention was higher than controls even 10 days following splenectomy. In another set of experiments, splenectomy was performed following which sepsis in rats was produced by cecal ligation and puncture. Ten hours following cecal ligation and puncture, the gangrenous cecum was removed and survival was measured over 5 days. The mortality rate in these animals was 57% (12/21) compared to 0% (0/8) in nonsplenectomized cecal ligated and punctured animals. These results suggest that splenectomy may not only have deleterious effects in terms of the host defense system, but may also cause prolonged pulmonary changes. |
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Authors:
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I H Chaudry; Y Tabata; S Schleck; A E Baue |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of trauma Volume: 20 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 1980 Aug |
Date Detail:
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Created Date: 1980-10-27 Completed Date: 1980-10-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 649-56 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cecum / injuries Fat Emulsions, Intravenous / pharmacology Immunity Iodine Radioisotopes Liver / metabolism Lung / drug effects, metabolism Mononuclear Phagocyte System / immunology, metabolism* Phagocytosis Rats Sepsis / mortality* Splenectomy / adverse effects* Time Factors Triolein / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Fat Emulsions, Intravenous; 0/Iodine Radioisotopes; 122-32-7/Triolein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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