Document Detail


Effect of spironolactone on urinary protein excretion in patients with chronic kidney disease.
MedLine Citation:
PMID:  20030528     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate antiproteinuric effect of spironolactone in patients with chronic kidney disease (CKD) treated with angiotensin-converting enzyme (ACE) inhibitors and/or angiotensin II type 1 receptor blockers (ARBs). METHODS: This study was performed in 33 CKD patients with proteinuria. 24 h urinary protein excretion and biochemical parameters were obtained before the therapy. Then, spironolactone (25 mg/d) was added to the therapy. The antiproteinuric effect of spironolactone was examined for eight weeks. RESULTS: At eight weeks, there was a significant decrease in proteinuria (p < 0.001, 47.9% decrease). Systolic and diastolic blood pressures were significantly decreased (p < 0.004, p < 0.001, respectively). However, no correlation was detected between the reductions in systolic and diastolic BP and the reduction in proteinuria (p = 0.464, p = 0.239, respectively). Serum potassium level increased significantly (p < 0.001). CONCLUSIONS: Our study suggests that spironolactone significantly reduces urinary protein excretion. This strategy may be useful to slow the progression of CKD. However, hyperkalemia is the most important side effect of treatment, and it is necessary to monitor potassium level. Further studies are needed to determine the efficacy of spironolactone on proteinuria.
Authors:
Erkan Sengul; Tayfun Sahin; Erce Sevin; Ahmet Yilmaz
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  31     ISSN:  1525-6049     ISO Abbreviation:  Ren Fail     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-24     Completed Date:  2010-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  England    
Other Details:
Languages:  eng     Pagination:  928-32     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey. dr.erkansengul@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aldosterone Antagonists / therapeutic use*
Female
Humans
Male
Middle Aged
Prospective Studies
Proteinuria / drug therapy*,  etiology
Renal Insufficiency, Chronic / complications*
Spironolactone / therapeutic use*
Chemical
Reg. No./Substance:
0/Aldosterone Antagonists; 52-01-7/Spironolactone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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