Document Detail

Effect of spinal cord stimulation on heart rate variability and myocardial ischemia in patients with chronic intractable angina pectoris--a prospective ambulatory electrocardiographic study.
MedLine Citation:
PMID:  9474464     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND HYPOTHESIS: Spinal cord stimulation is an effective treatment for chronic refractory angina pectoris. Its efficacy is related to an anti-ischemic action, possibly as a result of modulation of the autonomic nervous system. Therefore, the influence of spinal cord stimulation on the autonomic nervous system and myocardial ischemia was prospectively studied in 19 consecutive patients with intractable angina pectoris. METHODS: Patients were included when demonstrating > 0.1 mV STsegment depression on the exercise electrocardiogram (ECG) during two separate treadmill tests. After enrollment, heart rate variability together with ischemic indices were studied with 48 h ambulatory ECG monitoring. Assessments were made at baseline and after 6 weeks of spinal cord stimulation therapy. RESULTS: After 6 weeks, no significant changes in heart rate variability were detected. However, ischemic indices on the ambulatory ECG, as well as anginal attacks and consumption of sublingual nitrate tablets, were significantly decreased. CONCLUSION: Autonomic modulation assessable with heart rate variability analysis may not be the explanatory mechanism of action for the decrease of anginal attacks and ischemia, exerted by spinal cord stimulation used as an adjuvant therapy in patients with chronic intractable angina pectoris.
R W Hautvast; J Brouwer; M J DeJongste; K I Lie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  21     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-04-01     Completed Date:  1998-04-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33-8     Citation Subset:  IM    
Department of Cardiology, University Hospital, Groningen, The Netherlands.
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MeSH Terms
Angina Pectoris / physiopathology,  therapy*
Autonomic Nervous System / physiopathology
Chronic Disease
Electric Stimulation Therapy / methods*
Electrocardiography, Ambulatory*
Electrodes, Implanted
Exercise Test
Follow-Up Studies
Heart / innervation
Heart Rate / physiology*
Middle Aged
Myocardial Ischemia / physiopathology*,  therapy
Prospective Studies
Spinal Cord* / physiology
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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