Document Detail


Effect of spinal cord stimulation on cardiac adrenergic nerve function in patients with cardiac syndrome X.
MedLine Citation:
PMID:  18984456     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In patients with cardiac syndrome X (CSX) who present with refractory angina episodes, spinal cord stimulation (SCS) has beneficial effects. The mechanisms of SCS, however, remain speculative. We assessed the effects of SCS on cardiac sympathetic function in these patients. METHODS AND RESULTS: We studied 11 CSX patients treated by SCS for refractory angina (mean age, 60 +/- 9 years; 5 men and 6 women), both during SCS therapy (SCS-ON) and after withdrawal of SCS therapy (SCS-OFF), using a randomized crossover design. Planar and single photon emission computed tomography iodine 123 metaiodobenzylguanidine (MIBG) myocardial scintigraphy and technetium 99m sestamibi (MIBI) bicycle exercise stress testing were performed at the end of each period. Compared with 10 healthy control subjects, CSX patients showed a lower heart-mediastinum ratio for MIBG uptake (2.19 +/- 0.3 vs 1.69 +/- 0.3, P = .001) and a higher cardiac MIBG uptake score (4.0 +/- 2.5 vs 19.7 +/- 27, P = .08). There were no differences in CSX patients during the SCS-ON and SCS-OFF phases of the study in heart-mediastinum ratio (1.74 +/- 0.3 vs 1.69 +/- 0.3, P = .13), cardiac washout rate of MIBG (42.9% +/- 14% vs 43.3% +/- 14%, P = .08), or MIBG defect score (18.7 +/- 25 vs 19.7 +/- 27, P = .22). Reversible perfusion defects during the SCS-OFF phase were detected in 8 patients; an improvement in perfusion defects was observed in 2 patients (25%) during the SCS-ON phase. CONCLUSIONS: Our data confirm the presence of abnormal cardiac adrenergic nerve function in CSX patients. SCS was unable to result in significant improvement of cardiac MIBG uptake abnormalities, suggesting that its therapeutic effects are unlikely to be mediated by modulation of cardiac adrenergic nerve activity.
Authors:
Antonella Spinelli; Gaetano A Lanza; Maria Lucia Calcagni; Alfonso Sestito; Gregory A Sgueglia; Antonio Di Monaco; Isabella Bruno; Priscilla Lamendola; Lucy Barone; Alessandro Giordano; Filippo Crea
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Publication Detail:
Type:  Journal Article     Date:  2008-07-26
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  15     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-11-05     Completed Date:  2009-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  804-10     Citation Subset:  IM    
Affiliation:
Cardiology Institute, Università Cattolica del Sacro Cuore, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
3-Iodobenzylguanidine / pharmacology
Aged
Coronary Angiography / methods
Female
Humans
Iodine Radioisotopes / pharmacology
Male
Microvascular Angina / diagnosis,  pathology*
Middle Aged
Neurons / metabolism*
Radioisotopes / pharmacology
Receptors, Adrenergic / metabolism*
Spinal Cord / pathology*
Technetium Tc 99m Sestamibi / pharmacology
Tomography, Emission-Computed, Single-Photon / methods
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Radioisotopes; 0/Receptors, Adrenergic; 109581-73-9/Technetium Tc 99m Sestamibi; 77679-27-7/3-Iodobenzylguanidine

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