| Effect of spermine on association of protein kinase C with phospholipid vesicles. | |
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MedLine Citation:
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PMID: 2250564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The in vitro mechanism by which polyamines affect protein kinase C (PK C) activation process was investigated in a reconstituted system consisting of purified enzyme and phospholipid vesicles of various phosphatidylserine content. It was found that the addition of spermine greatly interferes with the association of PK C to liposomes. This tetramine, at micromolar concentrations, was most potently effective while other polyamines such as spermidine and putrescine were almost ineffective; therefore the modulatory action appeared to be structure specific. The spermine effect is dramatically influenced by the density of the phosphatidylserine present on the liposome, suggesting the complex formation with the acidic component on phospholipid vesicles to be the mechanism by which this polyamine exerts its modulatory action. |
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Authors:
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M S Moruzzi; M G Monti; G Piccinini; G Marverti; B Tadolini |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Life sciences Volume: 47 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1990 |
Date Detail:
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Created Date: 1991-01-16 Completed Date: 1991-01-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1475-82 Citation Subset: IM |
Affiliation:
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Istituto di Chimica Biologica, Università di Modena, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / enzymology Kinetics Liposomes / metabolism* Phorbol 12,13-Dibutyrate / metabolism Phosphatidylcholines / metabolism Phosphatidylserines / metabolism Protein Binding Protein Kinase C / metabolism* Rats Rats, Inbred Strains Spermine / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Liposomes; 0/Phosphatidylcholines; 0/Phosphatidylserines; 37558-16-0/Phorbol 12,13-Dibutyrate; 71-44-3/Spermine; EC 2.7.11.13/Protein Kinase C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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