| Effect of sperm treatment with exogenous platelet-activating factor on the outcome of intrauterine insemination. | |
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MedLine Citation:
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PMID: 15749490 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effect of sperm treatment with exogenous platelet-activating factor (PAF) on IUI clinical pregnancy rate. DESIGN: Prospective randomized study. SETTING: Assisted Reproduction Unit, 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece. SUBJECT(S): Fifty-two couples with unexplained infertility, candidates for IUI. INTERVENTION(S): Sperm treatment with an exogenous mixture of PAF (final concentration, 10(-7) mol/L) in sperm-washing medium, direct swim-up technique of sperm preparation, a maximum of six IUI cycles per couple with or without PAF treatment. MAIN OUTCOME MEASURE(S): Clinical pregnancy rate (pregnancies confirmed by ultrasonography per hundred cycles). RESULT(S): The overall clinical pregnancy rate after a maximum of six IUI cycles was significantly higher when sperm was treated with PAF compared with the rate after the direct swim-up technique (23.07% vs. 7.92%). CONCLUSION(S): Treatment of sperm with exogenous PAF might improve the clinical outcome of IUI in cases of unexplained infertility. |
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Authors:
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Odysseas Grigoriou; Evangelos Makrakis; Socrates Konidaris; Dimitrios Hassiakos; Konstantinos Papadias; Stavroula Baka; George Creatsas |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Fertility and sterility Volume: 83 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-07 Completed Date: 2005-05-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 618-21 Citation Subset: IM |
Affiliation:
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Assisted Reproduction Unit, 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Infertility / drug therapy* Insemination, Artificial, Homologous* Male Platelet Activating Factor / therapeutic use* Pregnancy Pregnancy Rate Prospective Studies Spermatozoa / drug effects* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Platelet Activating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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