Document Detail


Effect of sperm treatment with exogenous platelet-activating factor on the outcome of intrauterine insemination.
MedLine Citation:
PMID:  15749490     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the effect of sperm treatment with exogenous platelet-activating factor (PAF) on IUI clinical pregnancy rate. DESIGN: Prospective randomized study. SETTING: Assisted Reproduction Unit, 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece. SUBJECT(S): Fifty-two couples with unexplained infertility, candidates for IUI. INTERVENTION(S): Sperm treatment with an exogenous mixture of PAF (final concentration, 10(-7) mol/L) in sperm-washing medium, direct swim-up technique of sperm preparation, a maximum of six IUI cycles per couple with or without PAF treatment. MAIN OUTCOME MEASURE(S): Clinical pregnancy rate (pregnancies confirmed by ultrasonography per hundred cycles). RESULT(S): The overall clinical pregnancy rate after a maximum of six IUI cycles was significantly higher when sperm was treated with PAF compared with the rate after the direct swim-up technique (23.07% vs. 7.92%). CONCLUSION(S): Treatment of sperm with exogenous PAF might improve the clinical outcome of IUI in cases of unexplained infertility.
Authors:
Odysseas Grigoriou; Evangelos Makrakis; Socrates Konidaris; Dimitrios Hassiakos; Konstantinos Papadias; Stavroula Baka; George Creatsas
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Fertility and sterility     Volume:  83     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-07     Completed Date:  2005-05-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  618-21     Citation Subset:  IM    
Affiliation:
Assisted Reproduction Unit, 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Infertility / drug therapy*
Insemination, Artificial, Homologous*
Male
Platelet Activating Factor / therapeutic use*
Pregnancy
Pregnancy Rate
Prospective Studies
Spermatozoa / drug effects*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Platelet Activating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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