Document Detail

Effect of sperm subpopulation's kinetics on human fertilization in vitro.
MedLine Citation:
PMID:  16025857     Owner:  NLM     Status:  MEDLINE    
The present study was carried out to investigate the relationship between sperm subpopulation kinetics on in vitro fertilization rate. The ability of human sperm to achieve fertilization oocytes was investigated in relation to particular motility parameters obtained on a computer aided sperm analysis system base. Analysis covers velocity straight linear (VSL), cross beat frequency (CBF), lateral head displacement (LHD) and homogeneity of progressive motility velocity (HPMV) of fresh semen and semen after density gradient selection. Investigation was based on sperm samples from 82 infertile couples undergoing IVF. Two subpopulations were extracted from each sample using the clustering method with respect to VSL parameter: a slow and rapid one. Comparison of obtained results before and after selection shows no significant change of subpopulations percentage. However, this method of selection strongly influences motility parameters of both subpopulations. There was found a positive correlation for VSL, LHD and HPMV and a negative correlation for CBF parameters found in slow fraction of fresh semen and percentage of fertilized oocytes. On the other hand, rapid subpopulation parameters for fresh semen and parameters found for both subpopulations in semen after selection did not correlate with one. This means that information of slow sperm subpopulation kinetics carries important prognostic value of IVF success. Since the current prognosis factors ignore motility parameters of slow sperms, our results show the importance of such an analysis.
P Jedrzejczak; I Rzepczyńska; G Taszarek-Hauke; L Pawelczyk; M Kotwicka; W Warchoł
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of andrology     Volume:  51     ISSN:  0148-5016     ISO Abbreviation:  Arch. Androl.     Publication Date:    2005 May-Jun
Date Detail:
Created Date:  2005-07-19     Completed Date:  2005-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806755     Medline TA:  Arch Androl     Country:  England    
Other Details:
Languages:  eng     Pagination:  185-93     Citation Subset:  IM    
Division of Infertility and Reproductive Endocrinology, Department of Gynecology and Obstetrics, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
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MeSH Terms
Fertilization in Vitro*
Pregnancy Rate*
Sperm Motility / physiology*
Sperm-Ovum Interactions / physiology*
Spermatozoa / classification,  cytology*,  physiology

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