| Effect of specific lipoprotein(a) apheresis on coronary atherosclerosis regression assessed by quantitative coronary angiography. | |
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MedLine Citation:
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PMID: 23357149 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIM: To evaluate the effect of specific lipoprotein(a) [Lp(a)] apheresis on coronary atherosclerosis progression in coronary heart disease (CHD) patients with elevated Lp(a) levels. METHODS: A total of 30 subjects (mean age 53.5 ± 8.3 years, 70% male) with CHD verified by angiography, Lp(a) > 50 mg/dL, and low density lipoprotein cholesterol (LDL-C) ≤ 2.5 mmol/L on chronic statin treatment were prospectively evaluated for 18 months. Patients were allocated to receive specific Lp(a) apheresis, which was carried out weekly with Lp(a) Lipopak(®) columns (POCARD Ltd., Russia) (n = 15), or atorvastatin only (n = 15). Blinded quantitative coronary angiography analyses of percent diameter stenosis and minimal lumen diameter (MLD) were performed at baseline and after the 18-month treatment period. RESULTS: By the single specific Lp(a) apheresis procedure, Lp(a) level decreased by an average of 73 ± 12% to a mean of 29 ± 16 mg/dL, and mean Lp(a)-corrected LDL-C decreased by 7% to a mean of 1.4 mmol/L. Median percent diameter stenosis was reduced by -2.0 (95% confidence interval [CI], -5.0-0.0) with apheresis (p < 0.01 in comparison with baseline), and increased by 3.5 (0.0-6.9) with atorvastatin (p < 0.001 between the groups). The effect on MLD was more favorable with apheresis than with atorvastatin: 0.20 ± 0.39 mm, as compared with 0.01 ± 0.34 mm, p = 0.04. Lp(a) apheresis had greater efficacy regarding the amount of regressed/stabilized coronary segments than atorvastatin alone in the majority of patients (chi-square test 13.61, p < 0.005). CONCLUSION: Specific Lp(a) apheresis for 18 months produced coronary atherosclerosis regression in stable CHD patients with high Lp(a) levels and reached LDL-C goals. |
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Authors:
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Maya S Safarova; Marat V Ezhov; Olga I Afanasieva; Yuriy G Matchin; Ruslan V Atanesyan; Irina Yu Adamova; Elena A Utkina; Gennadiy A Konovalov; Sergei N Pokrovsky |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Atherosclerosis. Supplements Volume: 14 ISSN: 1878-5050 ISO Abbreviation: Atheroscler Suppl Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100973461 Medline TA: Atheroscler Suppl Country: Netherlands |
Other Details:
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Languages: eng Pagination: 93-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Cardiology Research Center 15A, 3rd Cherepkovskaya Street, 121552 Moscow, Russia. Electronic address: Dr.Safarova@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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