Document Detail

Effect of the specific angiotensin antagonist (Sar1) (Ala8) angiotensin II on blood pressure and the renin-angiotensin system in the conscious pregnant ewe and fetus.
MedLine Citation:
PMID:  696788     Owner:  NLM     Status:  MEDLINE    
A direct relationship was found between maternal diastolic blood pressure and simultaneously measured angiotensin II (All) levels (P less than 0.001) in chronically cannulated pregnant ewes. The infusion of Saralasin to the ewe resulted in a dose-dependent fall in blood pressure (P less than 0.005), the magnitude of which was proportional to the initial All levels (P less than 0.025). Plasma renin and All levels rose significantly during the infusion. No consistent fetal effects were seen. The infusion of normal saline had no effect on blood pressure or hormone levels. Thus it seems likely that the renin-angiotensin system is involved with the maintenance of normal blood pressure in the pregnant sheep. Fetal blood pressure either fell significantly or was unchanged following direct infusion of Saralasin. This may be related to development of the beta-adrenergic nervous system. The renin-angiotensin system may be more important in cardiovascular homeostasis in the immature than in the adult animal.
F Broughton Pipkin; P M O'Brien
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  132     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1978-11-18     Completed Date:  1978-11-18     Revised Date:  2004-08-19    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7-15     Citation Subset:  AIM; IM    
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MeSH Terms
Aldosterone / blood
Angiotensin II / analogs & derivatives*,  blood,  physiology*
Blood Pressure / drug effects*
Dose-Response Relationship, Drug
Fetus / physiology
Heart Rate / drug effects
Pregnancy, Animal*
Renin / blood,  physiology*
Saralasin / pharmacology*
Sodium Chloride / pharmacology
Reg. No./Substance:
11128-99-7/Angiotensin II; 34273-10-4/Saralasin; 52-39-1/Aldosterone; 7647-14-5/Sodium Chloride; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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