Document Detail

Effect of space flight on cytokine production.
MedLine Citation:
PMID:  11539514     Owner:  NASA     Status:  MEDLINE    
Space flight has been shown to alter many immunological responses. Among those affected are the production of cytokines. Cytokines are the messengers of the immune system that facilitate communication among cells that allow the interaction among cells leading to the development of immune responses. Included among the cytokines are the interferons, interleukins, and colony stimulating factors. Cytokines also facilitate communication between the immune system and other body systems, such as the neuroendocrine and musculoskeletal systems. Some cytokines also have direct protective effects on the host, such as interferon, which can inhibit the replication of viruses. Studies in both humans and animals indicate that models of space flight as well as actual space flight alter the production and action of cytokines. Included among these changes are altered interferon production, altered responsiveness of bone marrow cells to granulocyte/monocyte-colony stimulating factor, but no alteration in the production of interleukin-3. This suggests that there are selective effects of space flight on immune responses, i.e. not all cytokines are affected in the same fashion by space flight. Tissue culture studies also suggest that there may be direct effects of space flight on the cells responsible for cytokine production and action. The results of the above study indicate that the effects of space flight on cytokines may be a fundamental mechanism by which space flight not only affects immune responses, but also other biological systems of the human.
G Sonnenfeld
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta astronautica     Volume:  33     ISSN:  0094-5765     ISO Abbreviation:  Acta Astronaut     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1997-08-24     Completed Date:  1997-08-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9890631     Medline TA:  Acta Astronaut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  143-7     Citation Subset:  S    
Department of Microbiology and Immunology, University of Louisville, KY 40292, USA.
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MeSH Terms
Cells, Cultured
Colony-Stimulating Factors / biosynthesis,  physiology
Cytokines / biosynthesis*,  physiology*
Interferons / biosynthesis,  physiology
Interleukins / biosynthesis,  physiology
Space Flight*
Weightlessness / adverse effects*
Weightlessness Simulation
Reg. No./Substance:
0/Colony-Stimulating Factors; 0/Cytokines; 0/Interleukins; 9008-11-1/Interferons
G Sonnenfeld / Carolinas Med Ctr, Charlotte, NC

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