Document Detail


Effect of soy isoflavone supplementation on nitric oxide metabolism and blood pressure in menopausal women.
MedLine Citation:
PMID:  22552034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Isoflavones, having chemical structures similar to estrogens, are believed to stimulate nitric oxide production and thus lower blood pressure. The efficacy of soy isoflavone supplementation to stimulate nitric oxide production and lower blood pressure in menopausal women with high normal blood pressure remains unknown.
OBJECTIVE: The objective was to test the effect of soy isoflavone supplementation on nitric oxide production and blood pressure in menopausal women with high normal blood pressure.
DESIGN: A randomized, double-blind, parallel, placebo-controlled 6-wk trial was conducted to assess the effects of daily supplementation with 80 mg soy hypocotyl isoflavones (in aglycone units) on nitric oxide metabolism and blood pressure in 24 menopausal women with 12 women per group. Changes in nitric oxide metabolism were assessed via a primed, constant-infusion protocol with [15N]arginine and [13C]- and [2H]citrulline. Changes in blood pressure and associated vascular hemodynamics were assessed via office and 24-h ambulatory blood pressure monitoring, forearm blood flow, and indexes of arterial compliance.
RESULTS: When compared with placebo and after control for pretreatment values, soy isoflavone supplementation had no effect on arginine flux, citrulline flux, nitric oxide synthesis, blood pressure, forearm blood flow, or estimates of arterial stiffness.
CONCLUSION: Daily supplementation with 80 mg soy hypocotyl isoflavones over a 6-wk period had no effect on nitric oxide metabolism or blood pressure and associated vascular hemodynamics in menopausal women with high normal blood pressure.
Authors:
William W Wong; Addison A Taylor; E O'Brian Smith; Stephen Barnes; David L Hachey
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-05-02
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  95     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-21     Completed Date:  2012-07-27     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1487-94     Citation Subset:  AIM; IM    
Affiliation:
U.S. Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA. wwong@bcm.edu
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects*
Dietary Supplements*
Double-Blind Method
Female
Humans
Hypocotyl
Isoflavones / pharmacology*
Menopause / drug effects*,  physiology
Middle Aged
Nitric Oxide / metabolism*
Plant Extracts / pharmacology*
Soybeans / chemistry*
Grant Support
ID/Acronym/Agency:
1R01AG19325-01A1/AG/NIA NIH HHS; M01-RR00188/RR/NCRR NIH HHS; S10 RR19231-01/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Isoflavones; 0/Plant Extracts; 10102-43-9/Nitric Oxide
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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