Document Detail

Effect of some organic acid salts of tris(hydroxymethyl)aminomethane in the incubation step on plasma renin activity.
MedLine Citation:
PMID:  6994936     Owner:  NLM     Status:  MEDLINE    
The tris(hydroxymethyl)aminomethane salts of the organic acids acetylsalicylic, phenoxyacetic, salicylic, benzoic, acetic, and maleic were used to buffer the pH of plasma between 7.4 and 7.7 in a 1 h incubation step of the procedure for the determination of plasma renin activity. When compared to the plasma renin activity determined with tris(hydroxymethyl)aminomethane hydrochloride or with no buffer, it was found that all of the tris(hydroxymethyl)aminomethane salts of the organic acids studied produced a statistically significant increase in plasma renin activity except the salt of acetic acid when compared to tris(hydroxymethyl)aminomethane hydrochloride. In comparison to tris(hydroxymethyl)aminomethane hydrochloride and unbuffered plasma the organic acid salts and their mean percent difference in plasma renin activity are as follows: tris(hydroxymethyl)aminomethane phenoxyacetate (101%, 105%); tris(hydroxymethyl)aminomethane acetylsalicylate (79%, 115%); tris(hydroxymethyl)aminomethane benzoate (70%, 107%); tris(hydroxymethyl)aminomethane salicylate (64%, 70%); tris(hydroxymethyl)aminomethane maleate (32%, 60%); and tris(hydroxymethyl)aminomethane acetate (--1.6%, 43%).
M G Frazer; D E Pearson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  105     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  117-22     Citation Subset:  IM    
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MeSH Terms
Acetates / pharmacology
Angiotensin I / immunology
Aspirin / pharmacology
Benzoates / pharmacology
Hydrogen-Ion Concentration
Maleates / pharmacology
Phenoxyacetates / pharmacology
Renin / blood,  metabolism*
Salicylates / pharmacology
Tromethamine / pharmacology*
Reg. No./Substance:
0/Acetates; 0/Benzoates; 0/Buffers; 0/Maleates; 0/Phenoxyacetates; 0/Salicylates; 50-78-2/Aspirin; 77-86-1/Tromethamine; 9041-90-1/Angiotensin I; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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