Document Detail

Effect of sodium thiosulphate and cis-diamminedichloroplatinum on FADU tumour cells in nude mice.
MedLine Citation:
PMID:  16343395     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To study the effect of cis-diamminedichloroplatinum (CDDP) on FADU squamous cell carcinoma cells in a nude mouse model and to determine the effect of sodium thiosulphate (STS) on CDDP activity. METHODS: CD1 nude mice were inoculated with FADU tumour cells to both flanks. They were then randomized to four treatment groups: control, CDDP only, STS only, or CDDP and STS. Tumour growth was measured using calipers and charted at 3-day intervals. RESULTS: Tumour volumes were calculated as an ellipsoid and charted against time. CONCLUSIONS: CDDP inhibited FADU tumour cell growth compared with saline controls (p < .005). The addition of STS did not inhibit the CDDP activity when compared with CDDP-alone activity (p = .989). Compared with saline control solution, STS alone also inhibited tumour growth significantly (p < .005).
Norbert R Viallet; Brian W Blakley; Asher Begleiter; Marsha K Leith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of otolaryngology     Volume:  34     ISSN:  0381-6605     ISO Abbreviation:  J Otolaryngol     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-13     Completed Date:  2006-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7610513     Medline TA:  J Otolaryngol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  371-3     Citation Subset:  IM    
Department of Otolaryngology, University of Manitoba, Winnipeg, MB.
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MeSH Terms
Antineoplastic Agents / adverse effects,  therapeutic use*
Antioxidants / pharmacology*,  therapeutic use
Carcinoma, Squamous Cell / drug therapy*,  pathology
Cisplatin / adverse effects,  therapeutic use*
Disease Models, Animal
Drug Interactions
Hearing Loss / chemically induced,  prevention & control
Kidney Diseases / chemically induced,  prevention & control
Mice, Nude
Neoplasm Transplantation
Random Allocation
Stomach Neoplasms / drug therapy*,  pathology
Thiosulfates / pharmacology*,  therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Antineoplastic Agents; 0/Antioxidants; 0/Thiosulfates; 15663-27-1/Cisplatin; 7772-98-7/sodium thiosulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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