| Effect of sodium thiosulphate and cis-diamminedichloroplatinum on FADU tumour cells in nude mice. | |
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MedLine Citation:
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PMID: 16343395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To study the effect of cis-diamminedichloroplatinum (CDDP) on FADU squamous cell carcinoma cells in a nude mouse model and to determine the effect of sodium thiosulphate (STS) on CDDP activity. METHODS: CD1 nude mice were inoculated with FADU tumour cells to both flanks. They were then randomized to four treatment groups: control, CDDP only, STS only, or CDDP and STS. Tumour growth was measured using calipers and charted at 3-day intervals. RESULTS: Tumour volumes were calculated as an ellipsoid and charted against time. CONCLUSIONS: CDDP inhibited FADU tumour cell growth compared with saline controls (p < .005). The addition of STS did not inhibit the CDDP activity when compared with CDDP-alone activity (p = .989). Compared with saline control solution, STS alone also inhibited tumour growth significantly (p < .005). |
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Authors:
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Norbert R Viallet; Brian W Blakley; Asher Begleiter; Marsha K Leith |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of otolaryngology Volume: 34 ISSN: 0381-6605 ISO Abbreviation: J Otolaryngol Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-13 Completed Date: 2006-04-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7610513 Medline TA: J Otolaryngol Country: Canada |
Other Details:
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Languages: eng Pagination: 371-3 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, University of Manitoba, Winnipeg, MB. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / adverse effects, therapeutic use* Antioxidants / pharmacology*, therapeutic use Carcinoma, Squamous Cell / drug therapy*, pathology Cisplatin / adverse effects, therapeutic use* Disease Models, Animal Drug Interactions Female Hearing Loss / chemically induced, prevention & control Humans Kidney Diseases / chemically induced, prevention & control Mice Mice, Nude Neoplasm Transplantation Random Allocation Stomach Neoplasms / drug therapy*, pathology Thiosulfates / pharmacology*, therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Antioxidants; 0/Thiosulfates; 15663-27-1/Cisplatin; 7772-98-7/sodium thiosulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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