Document Detail


Effect of sodium pool changes on blood pressure in patients undergoing PFD: design of a prospective randomized multicenter trial.
MedLine Citation:
PMID:  11439738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Blood pressure control is important during dialysis and the interdialytic period because of the frequency and potential seriousness of hypotension and hypertension. Water and sodium removal play an important role in the genesis of intradialytic cardiovascular instability or hypertension. Changing dialysate sodium concentrations without the aid of a kinetic model can sometimes give good results but is only an empirical approach. Therefore, this clinical trial was designed to prospectively investigate the advantages of changes in the sodium pool on the blood pressure profile of patients undergoing paired filtration dialysis (PFD). The hypothesis to be tested is whether using a dialysate conductivity which, according to the conductivity kinetic model, ensures that the conductivity of the ultrafiltrate at the end of each dialysis session is 0.3 mS/cm more (B) or less (C) than the mean during the run-in period, improves blood pressure control either in patients prone to intradialytic hypotension or patients who are hypertensive or normotensive with antihypertensive treatment. Patients will be randomly allocated to one of two treatment sequences (where treatment A is standard PFD): AABB or ABAA for patients with intradialytic hypotension; AACC or ACAA for hypertensive patients. During the experimental phase arterial blood pressure will be measured and symptoms reported by the patients will be recorded.
Authors:
F Locatelli; S Andrulli; S Di Filippo; U Pozzoli; C Tetta
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of nephrology     Volume:  14     ISSN:  1121-8428     ISO Abbreviation:  J. Nephrol.     Publication Date:    2001 May-Jun
Date Detail:
Created Date:  2001-07-06     Completed Date:  2002-06-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9012268     Medline TA:  J Nephrol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  157-61     Citation Subset:  IM    
Affiliation:
Department of Nephrology and Dialysis, A. Manzoni Hospital, Lecco, Italy. nefrologia@ospedale.lecco.it
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / physiology*
Cross-Over Studies
Hemodiafiltration*
Humans
Multicenter Studies as Topic / methods*
Prospective Studies
Randomized Controlled Trials as Topic / methods*
Sodium / metabolism*
Chemical
Reg. No./Substance:
7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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